protein
| CDK4, PSMC4 |
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directly binds to NF-kappaB/RELA and exports RELA from nucleus through a chromosomal region maintenance-1 (CRM1) dependent pathway, which results in the cytoplasmic retention of NF-kappaB/RELA (Chen 2008) |
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PSMD10 expression is regulated by a positive feedback loop involving CTNNB1, which may play a critical role in tumorigenesis and the progression of Hepatocellular carcinoma P |
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CDH1 was found to be involved in the PSMD10 induced invasion of breast cancer cells due to hypoxia |
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PSMD10 was physically associated with ATG7 in the cytoplasm, and this association was enhanced by initial nutrient deprivation |
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oncoprotein that facilitates the degradation of two key tumor suppressors, namely, RB1 and TP53 |
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interact with the Kelch domain of KEAP1 and effectively competed with NFE2L2 for KEAP1 binding |
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involved in the inhibition of differentiation of hepatic stem cells (HSC) via triggering degradation of tumor suppressor proteins RB1, TP53, CEBPA and HNF4A |
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CELF1 is both a tumor suppressor and target of PSMD10-mediated degradation when unphosphorylated at Ser302 |
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PSMD10-mediated reduction of CELF1 is critical for the development of hepatoblastoma (HBL) |
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PSMD10 is a novel downstream effector of KDM4A |