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FLASH GENE
Symbol PSMC3 contributors: mct/npt - updated : 09-10-2009
HGNC name proteasome (prosome, macropain) 26S subunit, ATPase, 3
HGNC id 9549
Location 11p11.2      Physical location : 47.440.319 - 47.448.024
Synonym name
  • Tat-binding protein 1
  • proteasome subunit P50
  • human immunodeficiency virus tat transactivator binding
    • protein-1
    Synonym symbol(s) TBP1, MGC8487, TBP-1
    DNA
    TYPE functioning gene
    STRUCTURE 7.70 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 1618 - 439 - Pollice (2007)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus    
    Digestiveesophagus   highly
     liver    
     salivary gland   highly
    Nervousbrain    
    Reproductivefemale systemuteruscervix highly
     male systemprostate   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal domain possessing the leucine zipper structure
  • one AAA family chaperone-like (adenosine triphosphatases associated with diverse cellular activities)
    • HOMOLOGY
    Homologene
    FAMILY
  • PSM, proteasome family
  • AAA ATPase family
    • CATEGORY chaperone/stress , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • 19/22S regulator of proteasome, ATPase subunit contributing to the E3 ubiquitin ligase function of the VHL protein
  • involved in the ATP-dependent degradation of ubiquitinated protein
  • involvement in the control of cell proliferationb (Pollice 2004)
  • multifunctional protein, component of the regulatory subunit of the proteasome, involved in different cellular processes (Pollice 2007)
  • involved in protection of the human oncosuppressor CDKN2A from proteasomal degradation (Pollice 2007)
  • adenosine triphosphatase of 19S regulatory particles of the 26S proteasome, and transcriptional coactivator of thyroid hormone receptor (Satoh 2009)
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component 26S (prosome-macropain) of multicatalytic proteinase complex of proteasome
  • complexing with VHL and HIF1A
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • VHL, HIF1A
  • interacts with the human immunodeficiency virus tat transactivator
  • directly bound PSMC3IP through the N-terminal domain possessing the leucine zipper structure (Satoh 2009)
  • directly binds AR and might participate in AR-mediated transcriptional activation in cooperation with PSMC3IP (Satoh 2009)
  • interacting with CDKN2A (Pollice 2004))
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS