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FLASH GENE
Symbol PSMC1 contributors: mct/npt - updated : 17-07-2008
HGNC name proteasome (prosome, macropain) 26S subunit, ATPase, 1
HGNC id 9547
Location 14q32.11      Physical location : 90.722.893 - 90.738.964
Synonym name
  • 26S protease regulatory subunit 4
  • proteasome 26S subunit, ATPase, 1
    • Synonym symbol(s) S4, P56, P26S4, MGC8547, MGC24583
    DNA
    TYPE functioning gene
    STRUCTURE 16.07 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 1586 49 440 - Ewing (2007)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestivepharynx   highly
    Endocrinepancreas   highly
    Hearing/Equilibriumear   highly
    Nervousbrain   highly
    Reproductivefemale systemovary  highly
    Respiratorylung   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Psmc1
    homolog to Drosophila Pros26.4
    homolog to C.elegans rpt.2
    Homologene
    FAMILY
  • PSM, proteasome family
  • AAA ATPase family
    • CATEGORY chaperone/stress , enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • an ATPase-like subunit of the 19 S proteasome component
    • CELLULAR PROCESS protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • ATPase subunit of the 26 S (prosome-macropain) multicatalytic proteinase complex of proteasome
    • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
    • protein
  • interacts with HBX and PSMA7
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS