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FLASH GENE
Symbol PSMB9 contributors: mct - updated : 22-08-2014
HGNC name proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional protease 2)
HGNC id 9546
Location 6p21.3      Physical location : 4.054.044 - 32.827.626
Synonym name
  • low molecular mass polypeptide 2
  • proteasome subunit beta-1i
  • proteasome subunit beta 6i
  • multicatalytic endopeptidase complex chain 7
  • really interesting new gene 12 protein
  • Synonym symbol(s) LMP2, MPC2, RING12, beta1i, PSMB6i, MGC70470
    EC.number 3.4.25.1
    DNA
    TYPE functioning gene
    STRUCTURE 5.69 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    regionally located located in the class II region of the MHC
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 splicing 1048 23.3 219 - 1992 1429565
    also called LMP2.L
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrain    
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Psmb9
    homolog to C.elegans pbs-1
    Homologene
    FAMILY
  • peptidase T1B family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • involved in the degradation of cytoplasmic antigens for MHC class I antigen presentation pathways
  • involved in an ATP/ubiquitin-dependent non-lysosomal proteolytic pathway
  • unexpected role for the immunoproteasome subunit PSMB9 in antiviral humoral and innate immune responses
  • subunit of the immunoproteasome that is overexpressed in oncocytic lesions of the thyroid gland
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS immunity/defense
    text anti-pathogen response
    PATHWAY
    metabolism
    signaling
    a component
  • component 20 S (prosome-macropain) of multicatalytic proteinase complex of proteasome
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • IFNG directly controls IL33 protein level through a STAT1- and PSMB9-dependent mechanism
  • cell & other
    REGULATION
    induced by gamma interferon
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveuterus
    role of PSMB9 as a tumor suppressor may lead to new therapeutic targets in human uterine leiomyosarcoma
    ANIMAL & CELL MODELS