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FLASH GENE
Symbol PSMA7 contributors: mct - updated : 04-10-2014
HGNC name proteasome (prosome, macropain) subunit, alpha type, 7
HGNC id 9536
Location 20q13.33      Physical location : 60.711.790 - 60.718.474
Synonym name
  • proteasome subunit RC6-1
  • proteasome subunit XAPC7
  • Synonym symbol(s) XAPC7, PSA7, C6, HSPC, MGC3755, RC6-1
    EC.number 3.4.25.1
    DNA
    TYPE functioning gene
    STRUCTURE 6.73 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC391260 20 similar to cadherin 4, type 1 preproprotein; cadherin 4, R-cadherin (retinal); R-cadherin; retinal cadherin CDH4 20q13.3 cadherin 4, type 1, R-cadherin (retinal) FLJ22202 20q13.33 hypothetical protein FLJ22202 TAF4 20q13.3 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa C20orf40 20q13.33 chromosome 20 open reading frame 40 PSMA7 20q133 proteasome (prosome, macropain) subunit, alpha type, 7 SS18L1 20q13.2-q13.3 synovial sarcoma translocation gene on chromosome 18-like 1 GTPBP5 20 GTP binding protein 5 (putative) HRH3 20q13.3 histamine receptor H3 OSBPL2 20q13.3 oxysterol binding protein-like 2 ADRM1 20q13.33 adhesion regulating molecule 1 LAMA5 20q13.2-q13.3 laminin, alpha 5 RPS21 20q13.3 ribosomal protein S21 C20orf150 20q13.33 chromosome 20 open reading frame 150 C20orf151 20q13.33 chromosome 20 open reading frame 151 GATA5 20q11.21-q11.22 GATA binding protein 5 RPL7P3 20q13.33 ribosomal protein L7 pseudogene 3 C20orf166 20q13.33 chromosome 20 open reading frame 166 FLJ30313 20q13.33 hypothetical protein FLJ30313 LOC388805 20 LOC388805 FLJ32154 20q13.33 hypothetical protein FLJ32154 SLCO4A1 20q13.33 solute carrier organic anion transporter family, member 4A1 NTSR1 20q13 neurotensin receptor 1 (high affinity)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1050 - 248 - 2008 18202793
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemovary  highly
     female systemuteruscervix highly
     male systemprostate  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines several cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Psma7
    intraspecies homolog to PSMA2
    Homologene
    FAMILY proteasome a-type family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • involved in an ATP/ubiquintin-dependent non-lysosomal proteolytic pathway
  • be a target interacting with some important proteins involved in transcription factor regulation, cell cycle transition, viral replication and even tumor initiation and progression
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    text proteoysis and peptidolysis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HBX (interfere with activities of the proteasome complex)
  • CRYAB
  • AIMP1 into the cytoplasmic compartment interacts with its cytoplasmic partner PSMA7, a component of the proteasome degradation pathway
  • PSMA7 is a negative regulator of the MAVS-mediated innate immunity that probably serves to attenuate the establishment of an antiviral state during viral infection
  • PPP3R1 binds to proteasome subunit alpha type 7 (PSMA7) and inhibits the transactivation activity of HIF1A via the proteasome pathway
  • PSMA7 is a negative regulator of the NOD1, and may promote tumor growth by its inhibitory role on NOD1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • is a potential tumor biomarker
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    pharmacological inhibition of PSMA7 may be a beneficial strategy in the treatment of colorectal cancer patients
    ANIMAL & CELL MODELS