Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PSMA6 contributors: mct - updated : 07-06-2016
HGNC name proteasome (prosome, macropain) subunit, alpha type, 6
HGNC id 9535
Location 14q13.2      Physical location : 35.761.573 - 35.786.673
Genatlas name multicatalytic endopeptidase complex iota chain
Synonym name
  • subunit Pros27 (Iota)
  • 27 kDa prosomal protein
  • Synonym symbol(s) MPC3, PSMA4, IOTA, p27K, PROS27
    EC.number 3.4.25.1
    DNA
    TYPE functioning gene
    STRUCTURE 38.92 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    motif repetitive sequence   other
    text structure HSMS006 microsatellite, represented by 12 alleles, is localized in intron 6 of the PSMA6 gene
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1016 - 227 - 2013 22882272
    7 - 1139 - 167 - 2013 22882272
    7 - 1091 - 246 - 2013 22882272
    6 - 996 - 167 - 2013 22882272
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Respiratorylung   moderately
    Skin/Tegumentskin   highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Psma6
    Homologene
    FAMILY to peptidase family T1A.
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • involved in an ATP/ubiquitin-dependent non-lysosomal proteolytic pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component 20 S (prosome-macropain) of multicatalytic proteinase complex of proteasome
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between PPP3CA and the 20S proteasome subunit PSMA6 that increased intracellular proteasomal activity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to Graves disease
  • to myocardial infarction
  • myocardial infarction and coronary artery disease
  • Variant & Polymorphism SNP , other
  • 189- and 191-bp alleles of HSMS006 were much less frequent in Graves' disease patients
  • increasing the risk of myocardial infarction
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS