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FLASH GENE
Symbol PSMA4 contributors: - updated : 07-04-2006
HGNC name proteasome (prosome, macropain) subunit, alpha type, 4
HGNC id 9533
Location 15q24.1      Physical location : 78.832.746 - 78.841.560
Synonym name
  • proteasome component C9
  • macropain subunit C9
  • multicatalytic endopeptidase complex subunit C9
  • proteasome subunit L
  • Synonym symbol(s) MGC12467, MGC24813, MGC111191, HC9, HsT17706
    EC.number 3.4.25.1
    DNA
    TYPE functioning gene
    STRUCTURE 8.00 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   moderately
     liver   moderately
     salivary gland   highly
    Reproductivemale systemtestis  moderately
    Urinarybladder   predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer complex
    HOMOLOGY
    Homologene
    FAMILY peptidase T1A family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION threonine endopeptidase activity, ATP-dependent
    CELLULAR PROCESS protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component 20S core alpha subunit of the proteasome
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP binding
    protein
  • interacting with the subunit alpha 7
  • interacting with PARK2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS