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FLASH GENE
Symbol PSMA1 contributors: mct - updated : 12-07-2022
HGNC name proteasome (prosome, macropain) subunit, alpha type, 1
HGNC id 9530
Location 11p15.2      Physical location : 14.526.422 - 14.665.180
Synonym name
  • subunit Pros30
  • protein P30-33K
  • proteasome nu chain
  • macropain subunit C2
  • 20S proteasome subunit alpha6
    • Synonym symbol(s) MPC4, PMSA3, PROS30, PSC2, PSA1, NU, HC2, MGC1667, MGC14542, MGC14575, MGC14751; MGC21459
    EC.number 3.4.25.1
    DNA
    TYPE functioning gene
    STRUCTURE 138.76 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1281 - 263 - 2011 21703233
    11 - 1498 - 269 - 2011 21703233
    5 - 926 - 130 - 2011 21703233
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Psma1
    Homologene
    FAMILY peptidase family T1A
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • involved in an ATP/ubiquitin-dependent non-lysosomal proteolytic pathway
  • exhibits endoribonuclease activity controlled by extra-cellular stimuli
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component 20 S (prosome-macropain) of multicatalytic proteinase complex of proteasome
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in fertilization failure (FF), occurring in intracytoplasmic sperm injection (ICSI) cycles
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS