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FLASH GENE

Symbol

PSD

contributors: mct/npt - updated : 26-09-2015

HGNC name	pleckstrin and Sec7 domain containing
HGNC id	9507

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	10q24.32      Physical location : 104.162.375 - 104.178.901
Synonym name	pleckstrin and Sec7 domain protein
	PH and SEC7 domain-containing protein 1
	exchange factor for ARF6
Synonym symbol(s)	KIAA2011, TYL, PSD1, hCG_25646, EFA6A,

DNA

TYPE	functioning gene
SPECIAL FEATURE	tail to tail
text	tightly linked to NKF2, in tail to tail orientation
STRUCTURE	17.52 kb     17 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002779 17 - 4185 NP_002770 - 1024 - 2009 19494129 EFA6A in primary cortical neuron promotes neurite extension, whereas EFA6As induces dendrite branching NM_001270965 18 splicing 3861 NP_001257894 - 1024 - 2009 1949412 NM_001270966 19 splicing 3382 NP_001257895 - 645 - 2009 1949412 EFA6AS - - - - - - - short isoform lacks the Sec7 domain, and it comprises the PH domain and the C-terminal region in primary cortical neurons EFA6A promotes neurite extension, whereas EFA6As induces dendrite branching

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain limbic system hippocampus   highly Homo sapiens Reproductive male system testis     highly Mus musculus Visual eye retina     highly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a Sec7 homology domain involved in protein transport between, to and from Golgi, and mediating GEF activity on ARF6
	a pleckstrin (PH) homology domain
	a C-terminal region with coiled-coil motifs

HOMOLOGY

interspecies	homolog to yeast Sec7
	homolog to murine Psdl

Homologene

FAMILY	PSD, pleckstrin SeC7 domain family
	guanine nucleotide exchange factors family

CATEGORY

signaling

SUBCELLULAR LOCALIZATION	plasma membrane,junction
	intracellular
text	partial colocalization of PSD and SNX1 in the dendritic fields of the hippocampus

basic FUNCTION	may form a protein complex with alpha-actinin and activate ARF6 in close proximity of the actin cytoskeleton and membrane proteins in the dendritic spines
	ARF6 and PSD may regulate the conversion of filopodia to spines and the stability of both early and mature spines
	possible involvement of PSD-ARF6 signaling in the karyokinesis and cytokinesis
	could participate in neuronal morphogenesis through the regulated expression of two functionally distinct isoforms
	participates in activation of ARF6 around the cleavage furrow during cytokinesis
	is an ARF6-specific guanine nucleotide exchange factor that is abundantly expressed in the brain
	regulates ARF6-mediated neurite formation through the interaction with SNX1
	likely recruits SH3GL2 on flat areas of the plasma membrane to control ARF6 activation and clathrin-mediated endocytosis
	PSD and cytohesins may combine in a mixed negative-positive feedback loop

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

PSD-ARF6 pathway may play a specific role at a subcompartment of perisynaptic photoreceptor processes

a component

compexing with ACTA1

INTERACTION

DNA

RNA

small molecule

protein	can specifically activate ADP ribosylation factor 6 (ARF6)
	act as a guanine nucleotide exchange factor (GEF) for ARF6
	GRASP is responsible for neuronal dendritic development via regulation of PSD/ARF6-mediated cytoskeleton dynamics
	PSD interacting with SH3GL2 that stimulates the catalytic activity of PSD on ARF6

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS