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FLASH GENE

Symbol

PSCA

contributors: mct - updated : 31-10-2013

HGNC name	prostate stem cell antigen
HGNC id	9500

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	8q24.3      Physical location : 143.751.725 - 143.764.144
Synonym symbol(s)	PRO232, UNQ206/PRO232

DNA

TYPE	functioning gene
STRUCTURE	12.42 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005672 3 - 1038 NP_005663 - 123 - 2002 11752398

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive intestine large intestine colon       stomach       highly Endocrine pancreas         Nervous brain         Reproductive male system prostate     highly Urinary bladder

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     highly Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage	at the basal cell epithelium, putative stem cell compartment of normal prostate
cell lines
fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	small protein containing an aminoacid signal sequence
	a C terminal glycosylphosphatidylinositol (GPI) anchoring sequence with ten cysteine residues
	multiple N-glycosylation sites
	one UPAR/LY6 domain

conjugated

GlycoP

HOMOLOGY

interspecies	homolog to murine Psca
	homolog to C.elegans F58B4.3

Homologene

FAMILY

CATEGORY

antigen

SUBCELLULAR LOCALIZATION	plasma membrane
text	anchored by a GPI linkage

basic FUNCTION	playing a role in prostate cancer progression
	tissue specific tumor suppressor or oncogene found to be associated with several human tumors including gallbladder cancer
	involved in the cell-proliferation inhibition and/or cell-death induction activity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

text	tumor antigen

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in prostate carcinoma

Susceptibility

to diffuse-type gastric cancer to bladder cancer to gallbladder carcinoma in females

Variant & Polymorphism SNP	increasing the risk of diffuse-type gastric cancer
	rs2294008 is the only common missense SNP in PSCA and is a new bladder cancer susceptibility locus
	rs2294008 and rs2978974, may be important for bladder cancer susceptibility, possibly through different mechanisms that influence the control of mRNA expression and interaction with regulatory factors
	significant association of Trs2294008-Grs2978974 haplotype with higher risk of gallbladder carcinoma in females

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive prostate ideal target for both diagnosis and therapy in prostate carcinoma cancer reproductive uterus PSCA and TBX2 might be candidate targets for cancer therapy in endometrial adenocarcinoma

ANIMAL & CELL MODELS