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FLASH GENE
Symbol PRUNE2 contributors: mct/npt - updated : 09-07-2015
HGNC name prune homolog 2 (Drosophila)
HGNC id 25209
Location 9q21.2      Physical location : 79.226.292 - 79.521.003
Genatlas name BNIP2 Extra Long
Synonym name
  • chromosome 9 open reading frame 65
  • KIAA0367
  • olfaxin
  • BNIP2 Extra Long
  • BNIP2 motif containing molecule at the carboxyl terminal region 1
  • BCH motif-containing molecule at the carboxyl terminal region 1
  • cDNA sequence, expressed in brain, >100kDa, E1B 19k/BCL2 interacting protein NIP2
    • Synonym symbol(s) C9orf65, BMCC1, BNIPXL, RP11-58J3.2, KIAA0367, A214N16.3, bA214N16.3, DKFZp762K117
    DNA
    TYPE functioning gene
    STRUCTURE 294.84 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 12522 336.91 3055 - 2012 23059019
    BNIPXL-beta
    19 - 12602 340.63 3088 - 2012 23059019
  • BNIPXL-alpha
    • - - - - - expressed predominantly in the olfactory bulb and layer Ia of the piriform cortex 2012 23059019
  • Olfaxin
  • contains a BCH motif and localizes predominantly to the synaptic cytosol, similar to ATCAY
  • may develop new roles for Prune2 at the synapse in olfactory systems
    • - - 12525 - 3063 - 2012 23059019
    - - 4587 - 337 - 2012 23059019
    - - 4542 40.09 352 - 2012 23059019
    - - 4458 - 324 - 2012 23059019
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  highly
    Nervousbrain   highly Homo sapiens
     nervecranial nervetrigeminal nerve highly Homo sapiens
     spinal cordsensory gangliadorsal root   Homo sapiens
     spinal cordanterior horn    Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • P-loop and a coiled-coil region near the N-terminus
  • a Bcl2-/adenovirus E1B interacting protein 2 (BNIP2)
  • Cdc42GAP homology domain in the C-terminus, with caspase cleavage sites upstream of the C-terminal BCH domain (Valencia 2007)
    • HOMOLOGY
    interspecies ortholog to PRUNE
    Homologene
    FAMILY BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may play an important role in regulating differentiation, survival and aggressiveness of the tumor cells (neuroblastoma)
  • BCH domain-containing protein implicated in programmed cell death (cleaved by caspases during apoptosis)(Valencia 2007)
  • could suppress cellular transformation by preventing sustained Rho activation in concert with restricting RHOA and AKAP13 binding via its BCH domain
  • involved in the regulation of protein degradation, apoptosis, neuronal loss and neurodevelopment
  • may contribute to the maintenance of mature nervous systems
  • novel role for BMCC1 in post-endocytic trafficking
  • is an AP2 associated endosomal protein in prostate cancer cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • PRUNE2 binds to 8-oxo-GTP, an oxidized form of GTP
    • protein interacting with RHOA, RHOC, and BNIP2 (Soh 2008)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in neuroblastoma with favorable prognosis
    tumoral     --over  
    during NGF-depletion-induced apoptosis in neuroblastoma and was involved in the regulation of differentiation, survival, and aggressiveness of tumor cells (Valencia 2007)
    tumoral     --over  
    increased PRUNE2 protein expression may serve as a favorable prognostic marker in human leiomyosarcoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS