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FLASH GENE
Symbol PRUNE contributors: mct/npt - updated : 11-01-2010
HGNC name prune homolog (Drosophila)
HGNC id 13420
Location 1q21.2      Physical location : 150.980.972 - 151.008.189
Synonym name
  • TcD37 homolog
  • Drosophila-related expressed sequence 17
  • Synonym symbol(s) HTCD37, DRES-17
    EC.number 3.6.1.1
    DNA
    TYPE functioning gene
    STRUCTURE 27.22 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2995 - 453 - Middelhaufe (2007)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text eye
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • PDE catalytic domain at the N-terminus and shown to be active, even when present in a monomeric form
  • a potential coiled-coil region in a C-terminal cortexillin homology domain, mediating its homodimerization, as well as its interaction with NME1 (Middelhaufe 2007)
  • HOMOLOGY
    interspecies ortholog to the Drosophila prune protein
    intraspecies homolog to PRUNE2
    Homologene
    FAMILY
  • DHH (Asp-His-His) superfamily of phosphoesterases
  • PPase class C family
  • Prune subfamily
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text localized to focal adhesions (Kobayashi 2006)
    basic FUNCTION
  • may be involved in cell migration (Kobayashi 2006)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • composed of two independent active sites and two interaction sites for the assembly of oligomeric signaling complexes (Middelhaufe 2007)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction partner and regulator of the metastasis suppressor protein NM23-H1 (NME1) (Middelhaufe 2007)
  • glycogen synthase kinase 3 (GSK3B)-binding protein (GSK3B and PRUNE cooperatively regulate the disassembly of focal adhesions to promote cell migration)(Kobayashi 2006)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal and pancreatic cancers, and the positivity of its expression was correlated with tumor invasion (Kobayashi 2006)
    Susceptibility
    Variant & Polymorphism
    Candidate gene useful as a marker for tumor aggressiveness (Kobayashi 2006)
    Marker
    Therapy target inhibition of PRUNE could be a therapeutic approach towards metastatic tumours (Middelhaufe 2007)
    ANIMAL & CELL MODELS