Selected-GenAtlas references SOURCE GeneCards NCBI Gene Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PRSS7 contributors: - updated : 19-07-2005
HGNC name protease, serine, 7 (enterokinase)
HGNC id 9490
Corresponding disease
PRSS7 enterokinase deficiency
Location 21q21      Physical location : -
Synonym name enteropeptidase
Synonym symbol(s) ENTK
EC.number 3.4.21.9
DNA
TYPE functioning gene
STRUCTURE 133.00 kb     25 Exon(s)
10 Kb 5' upstream gene genomic sequence study
motif repetitive sequence
text structure CA repeat at the 5' end of intron 6
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
cells
SystemCellPubmedSpeciesStageRna symbol
Digestiveepithelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two CUB,one MAM and one SEA domain
  • one SRCR domain
  • a catalytic (light) chain and a multidomain (heavy), chain linked by a disulfide bond
    • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Prss7
    Homologene
    FAMILY peptidase family S1
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text brush border
    basic FUNCTION
  • protease serine, enterokinase of the duodenal brush border membrane
  • activator of trypsinogen by cleavage, involved in the digestion
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PRSS7
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS