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FLASH GENE
Symbol PRSS57 contributors: mct - updated : 30-09-2014
HGNC name protease, serine, 57
HGNC id 31397
Location 19p13.3      Physical location : -
Synonym name
  • protease, serine-like 1
  • serine protease 1-like protein 1
  • neutrophil serine protease 4
  • Synonym symbol(s) NSP4, PRSSL1, UNQ782
    DNA
    TYPE functioning gene
    SPECIAL FEATURE opposite orientation
    text
  • transcribed in opposite direction, compared with AZU1-PRTN3-ELANE-CFD cluster
  • STRUCTURE 9.91 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1073 - 283 - 2012 22474388
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticgranulocyte Homo sapiens
    Blood/Hematopoieticneutrophil Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Prssl1
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • likely regulating neutrophil responses and innate immune reactions
  • azurophil granule protein of neutrophils
  • is a genuine member of preactivated serine proteases stored in azurophil granules of human neutrophils
  • exhibits a trypsin-like specificity for cleaving substrates after arginine residues, but it bears elastase-like specificity determining residues in the active site
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS