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FLASH GENE
Symbol PRSS50 contributors: mct - updated : 17-01-2011
HGNC name protease, serine, 50
HGNC id 17910
Location 3p21.31      Physical location : 46.753.605 - 46.759.373
Synonym name
  • cancer/testis antigen 20
  • testis-specific protease-like protein 50
  • testes specific protease 50
  • Synonym symbol(s) TSP50, CT20
    EC.number 3.4.25.-
    DNA
    TYPE functioning gene
    STRUCTURE 5.77 kb     6 Exon(s)
    regulatory sequence Promoter
    Binding site   transcription factor   HRE
    text structure
  • putative Sp1 binding site (+237 to +239) and the putative CCAAT/enhancer binding protein (C/EBP) binding site (-15 to -13), are more important for the basal transcription activity of the human TSP50 promoter
  • Sp1 site, located within the +237/+239 region of the promoter, is the major responsive element for FGF2
  • two BORIS binding sites in the PRSS50 promoter that are highly conserved
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1363 - 385 - 1999 10397268
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  specific Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/liningretinal pigment epithelium (RPE)  
    Epithelialsensoryvisual  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatocyte
    cell lineage
    cell lines mammary epithelial cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • peptidase family S1
  • CATEGORY enzyme , protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • involved in the spermatogenesis
  • testis-specific gene that encoded a threonine protease
  • role in signal-dependent transcriptional regulation
  • can enhance the expression of NFKB target genes involved in cell proliferation, and promotes cell proliferation, at least partially, through activation of the NFKB signalling pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with FGF2 (mediates PRSS50 downregulation by ERK activation, leading to the phosphorylation of Sp1 in this process)
  • CTCFL is directly responsible for the transcriptional activation of PRSS50
  • cell & other
    REGULATION
    activated by CTCFL
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    not only reduced cell proliferation, colony formation, and migration but also induced cell apoptosis in tumor cells
    tumoral     --over  
    in breast cancer cells and overexpression of PRSS50 can promote tumorigenesis
    tumoral     --low  
    in seminoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target development of new reagents for therapeutic downregulation of breast cancer
    ANIMAL & CELL MODELS