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FLASH GENE
Symbol PRSS1 contributors: mct/npt - updated : 26-08-2009
HGNC name protease, serine, 1 (trypsin 1)
HGNC id 9475
Corresponding disease
HPG hereditary pancreatitis
Location 7q34      Physical location : 142.457.318 - 142.460.927
Synonym name
  • trypsinogen 1
  • beta-trypsin
  • cationic trypsinogen
  • digestive zymogen
  • Synonym symbol(s) TRY1, TRYP1, PCTT, T1, TRY4, TRP1, MGC120175, MGC149362
    EC.number 3.4.21.4
    DNA
    TYPE functioning gene
    STRUCTURE 3.61 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map see TCRB
    Physical map
    TRBV6-9 7q34 T cell receptor beta variable 6-9 TRBV7-8 7q34 T cell receptor beta variable 7-8 TRBV5-8 7q34 T cell receptor beta variable 5-8 TRBV7-9 7q34 T cell receptor beta variable 7-9 TRBV13 7q34 T cell receptor beta variable 13 TRBV10-3 7q34 T cell receptor beta variable 10-3 TRBV11-3 7q34 T cell receptor beta variable 11-3 TRBV12-3 7q34 T cell receptor beta variable 12-3 TRBV12-4 7q34 T cell receptor beta variable 12-4 TRBV12-5 7q34 T cell receptor beta variable 12-5 TRBV14 7q34 T cell receptor beta variable 14 TRBV15 7q34 T cell receptor beta variable 15 TRBV16 7q34 T cell receptor beta variable 16 TRBV17 7q34 T cell receptor beta variable 17 TRBV18 7q34 T cell receptor beta variable 18 TRBV19 7q34 T cell receptor beta variable 19 TRBV20-1 7q34 T cell receptor beta variable 20-1 TRBV21-1 7q34 T cell receptor beta variable 21-1 TRBV22 7q34 T cell receptor beta variable 22 TRBV23-1 7q342 T cell receptor beta variable 23-1 TRBV24-1 7q34 T cell receptor beta variable 24-1 TRBV25-1 7q34 T cell receptor beta variable 25-1 TRBVA 7q34 T cell receptor beta variable A TRBV26 7q34 T cell receptor beta variable 26 TRBVB 7q34 T cell receptor beta variable B TRBV27 7q34 T cell receptor beta variable 27 TRBV28 7q34 T cell receptor beta variable 28 TRBV29-1 7q34 T cell receptor beta variable 29-1 PRSS1 7q35 protease, serine, 1 (trypsin 1) TRY5 7q34 trypsinogen B TRY6 7q34 trypsinogen C TRY7 7q34 trypsinogen D PRSS2 7q35 protease, serine, 2 (trypsin 2)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 821 - 247 - Yamamoto (1992)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Endocrinepancreas   highly
    Lymphoid/Immunethymus   highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text pancreas
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 15 AA signal
  • 8 AA activation sites
  • HOMOLOGY
    interspecies homolog to murine Try1
    Homologene
    FAMILY
  • peptidase family S1 (trypsin family)
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • protease serine, cationic trypsinogen, playing a role in peptide linkages involving the carboxyl group of lysine or arginine
  • playing a role in the digestion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS digestion
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PRSS2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HPG
    related resource Database of genetic variants in patients
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional fusion     gain of function
    PRSS1/PRSS2, exons 1 and 2 are derived from PRSS2 and exons 3-5 from PRSS1, apparently resulted from a non-allelic homologous recombination, with double gain-of-function effect in chronic pancreatitis
    Susceptibility to chronic pancreatitis, to pancreatic cancer
    Variant & Polymorphism other mutation loss of function protecting against pancreatitis
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS