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FLASH GENE
Symbol PRRG2 contributors: mct - updated : 11-12-2014
HGNC name proline rich Gla (G-carboxyglutamic acid) 2
HGNC id 9470
Location 19q13.33      Physical location : 50.084.586 - 50.094.265
Synonym name
  • Proline-rich Gla protein 2
  • Synonym symbol(s) PRGP2
    DNA
    TYPE functioning gene
    STRUCTURE 10.36 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1411 - 202 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestineileum highly Homo sapiens
     intestinesmall intestine  highly Homo sapiens
    Endocrinethyroid   highly Homo sapiens
    Urinarykidney   highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal gamma-carboxy-glutamate domain (Gla) domain, extracellular domain (Gla residues are produced after subsequent posttranslational modifications of glutamate by a vitamin K-dependent gamma- carboxylase)
  • a 49-AA signal/propeptide containing the highly conserved residues implicated in gamma-carboxylation
  • a transmembrane region
  • a proline-rich C-terminal region containing PPXY and PXXP motifs
  • a cytosolic WW binding motifs
  • HOMOLOGY
    interspecies ortholog to murine Prrg2
    Homologene
    FAMILY
    CATEGORY signaling hormone
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text type I membrane protein
    basic FUNCTION
  • may be involved in a signal transduction pathway, the impairment of which may be an unintended consequence of warfarin therapy
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Ca2+
    protein
  • NEDD4
  • PRRG2-initiated signaling events most likely depend on proteins with WW domains
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS