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FLASH GENE
Symbol PRR7 contributors: mct - updated : 04-02-2012
HGNC name proline rich 7 (synaptic)
HGNC id 28130
Location 5q35.3      Physical location : 176.873.795 - 176.883.285
DNA
TYPE functioning gene
STRUCTURE 9.49 kb     4 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1543 - 274 - 2011 21460222
3 - 1458 - 274 - 2011 21460222
3 - 1338 - 274 - 2011 21460222
EXPRESSION
Rna function
  • mRNA is expressed most strongly in brain tissue and moderately in several other tissues: esophagus, trachea, lung, ovary, cervix, prostate, testes, thyroid, including the immune organs thymus and lymph nodes
  • Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousnerve     Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte Homo sapiens
    Lymphoid/Immuneactivated B lymphocyte Homo sapiens
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a very short N-terminal extracellular region,
  • a single membrane spanning domain,
  • a potential submembrane palmitoylation motif (CCXC), AA 2831
  • a region critical for the apoptosis induction is located between AA 159 and 171
  • a cytoplasmic domain possessing a proline-rich sequence and a C-terminal type-1 PDZ binding motif
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • potentially involved in modulating neural activities via interactions with the NMDA receptor and DLG4, and PSD core formation
  • potential regulator of signaling and apoptosis in activated T cells
  • could be potentially involved in modulation of neural activities
  • its expression resulted in selective up-regulation of JUN and CD69, whereas at the same time it led to the inhibition of proximal TCR signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to the third PDZ domain of DLG4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS