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FLASH GENE
Symbol PRR13 contributors: mct/npt - updated : 24-03-2009
HGNC name proline rich 13
HGNC id 24528
Location 12q13.13      Physical location : 53.835.432 - 53.840.426
Synonym name taxane-resistance protein
Synonym symbol(s) FLJ23818, DKFZP564J157, TXR1
DNA
TYPE functioning gene
STRUCTURE 4.99 kb     4 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1262 15.25 148 - Lih (2006)
two variants differ only in their 5-prime UTRs
4 - 1113 10.4 98 - Lih ((2006)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 salivary gland   highly
Respiratoryrespiratory tractlarynx  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • impedes taxane-induced apoptosis in tumor cells by transcriptionally down-regulating the production of thrombospondin-1 (THBS1)--known earlier for both its anti-angiogenic and proapoptotic actions (Lih 2006)
  • regulator of THBS1 production and play a role for its chemotherapeutic modulation (Lih 2006)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS