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FLASH GENE
Symbol PRPF4B contributors: mct - updated : 02-03-2010
HGNC name PRP4 pre-mRNA processing factor 4 homolog B (yeast)
HGNC id 17346
Location 6p25.2      Physical location : 4.021.568 - 4.065.216
Synonym name serine/threonine protein kinasePRP4 homolog
Synonym symbol(s) PR4H, PRP4, PRP4H, PRP4K, KIAA0536, PR4B
EC.number 2.7.11.1
DNA
TYPE functioning gene
STRUCTURE 43.65 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 7482 - 1007 - 2000 10799319
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemprostate  highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • tyrosine kinase catalytic domain
  • N-terminal arginine/serine rich domain
  • putative nuclear localization signal
  • HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • CMGC Ser/Thr protein kinase family
  • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • involved in pre-mRNA splicing and signal transduction
  • mediating phosphorylation of KLF13 and thus playing a role in the regulation of CCL5 expression in T lymphocytes
  • is required for stable tri-snRNP association during spliceosomal B complex formation
  • phosphorylates PRPF6 and PRPF31, both components of the U4/U6-U5 tri-snRNP
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with CLK1(phosphorylation of PRPF4B)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS