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FLASH GENE
Symbol PRPF39 contributors: mct - updated : 14-05-2018
HGNC name PRP39 pre-mRNA processing factor 39 homolog (yeast)
HGNC id 20314
Location 14q21.2      Physical location : 45.553.301 - 45.584.802
Synonym symbol(s) FLJ20666, FLJ11128
DNA
TYPE functioning gene
STRUCTURE 31.50 kb     15 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 2894 - 669 - 2012 22773733
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemuterus   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine LOC328110
homolog to rattus LOC314171
Homologene
FAMILY
CATEGORY RNA associated
SUBCELLULAR LOCALIZATION     intracellular
basic FUNCTION
  • pre mRNA 3'end processing activity
  • role of PRPF39 in modulating cisplatin response
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA mRNA processing
    small molecule
    protein
  • role of PRPF39 as a potential regulator of TFDP2 represents an interesting area of further study regarding the role of TFDP2 and cisplatin response
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to variation of cisplatin sensitivity
    Variant & Polymorphism other
  • successful knockdown of PRPF39 expression using siRNA resulted in a significant increase in cisplatin resistance, and association of rs17115814 with resistance to cisplatin is likely due to its effect on PRPF39 gene expression and subsequent effects on multiple downstream targets
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS