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FLASH GENE
Symbol PRPF3 contributors: mct - updated : 23-01-2012
HGNC name PRP3 pre-mRNA processing factor 3 homolog (yeast)
HGNC id 17348
Corresponding disease
RP18 retinitis pigmentosa 18
Location 1q21.3      Physical location : 150.293.927 - 150.325.703
Synonym name U4/U6-associated RNA splicing factor
Synonym symbol(s) HPRP3, HPRP3P, PRP3
DNA
TYPE functioning gene
STRUCTURE 31.78 kb     16 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 2480 - 683 - 2002 1197189
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Visualeyeretina  highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Visualcone photoreceptor Homo sapiens
Visualrod photoreceptor Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a PWI domain commonly present in splicing factors
mono polymer heteromer , complex
HOMOLOGY
interspecies ortholog to yeast S.cerevisiae prp3
Homologene
FAMILY
CATEGORY RNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
intracellular,nucleus,nucleolus
text co-localizes with small nuclear ribonucleoproteins, partially with a nucleolar marker (may require chemical modifications in the nucleolus to become active)
basic FUNCTION
  • participating in pre-mRNA splicing
  • may play a role in the assembly of the U4/U5/U6 tri-snRNP complex
  • CSNK2A1 and PRPF3 are absolutely necessary for an efficient splicing whereas CSNK2A2 seems to be dispensable
  • CELLULAR PROCESS nucleotide, RNA splicing
    protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling sensory transduction/vision
    a component
  • spliceosome made up of 4 snRNPs, a number of transiently associated splicing factors and a premRNA
  • with PRPF31 and PRPF8, are component of the spliceosome, a macromolecular complex that processes nearly all pre-mRNAs
  • INTERACTION
    DNA
    RNA binding to U4 and U6 snRNAs
    small molecule
    protein
  • HPRP4P
  • RASSF1C and spliceosome component PRPF3 interacting with EMC2
  • CSNK2A1 interacts with the splicing factor PRPF3, which is important for the assembly of the spliceosome
  • cell & other
    REGULATION
    Other spliceosomal PRPF19 complex modifies PRPF3, a component of the USP4, with nonproteolytic K63-linked ubiquitin chains
    ASSOCIATED DISORDERS
    corresponding disease(s) RP18
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS