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FLASH GENE
Symbol PRPF19 contributors: mct - updated : 14-10-2014
HGNC name PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)
HGNC id 17896
Location 11q12.2      Physical location : 60.658.020 - 60.674.061
Synonym name
  • PRP19/PSO4 pre-mRNA processing factor 19 homolog
  • nuclear matrix protein NMP200 related to splicing factor PRP19
  • senescence evasion factor
    • Synonym symbol(s) NMP200, PRP19, PSO4, SNEV, UBOX4
    DNA
    TYPE functioning gene
    STRUCTURE 16.04 kb     16 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 2342 - 504 - 2010 2017681
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Reproductivefemale systemuteruscervix highly
     male systemprostate  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a domain of AAs 167-250 is necessary for the recruitment of PRPF19 to lipid droplets and a domain of AAs 1-166 is necessary for the recruitment of PRPF19 to a nucleus
  • C-terminal WD40 region
    • HOMOLOGY
    interspecies ortholog to yeast Prp19
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text
  • found in the nucleus, cytosol or lipid droplets depending on the cell type
    • basic FUNCTION
  • playing a role in pre-mRNA splicing, but also having a direct role in DNA damage processing
  • extending the cellular life span by increasing the resistance to stress or by improving the DNA repair capacity of the cells
  • nuclear matrix protein involved in pre-mRNA splicing, ubiquitylation, and DNA repair
  • involved in pre-mRNA splicing, having an essential role for spliceosome assembly and spliceosome stability
  • is necessary to bring SETMAR to the DSB sites for its function(s) in DNA repair
  • once it forms a complex with SETMAR, negatively regulates its TIR binding activity, which is perhaps necessary for SETMAR localization at non-TIR sites such as double-strand breaks
  • spliceosomal PRPF19 complex modifies PRPF3, a component of the USP4, with nonproteolytic K63-linked ubiquitin chains
  • multi-functional protein that plays a role in splicing, ubiquitination, and cell growth
  • both U2AF2 and PRPF19 are required for RNA polymerase II C-terminal domain-dependent splicing activation
  • PRPF19 splicing complex is potentially a novel transcription elongation factor
  • involved in cellular life-span regulation and proteasomal breakdown
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • PRPF19 and its related proteins are major components of the spliceosome catalytic core RNP
  • PRPF19/CDC5L complex contains four copies of PRPF19
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with WRN through a direct physical association between WRN and CDC5L
  • SETMAR binding partner that mediates SETMAR binding to non-TIR DNA such as DNA damage sites
  • is involved in DNA repair and splicing, associates with the proteasome by directly binding to the beta7 subunit of the 20 S proteasome
  • CTNNBL1 associates with the PRPF19 complex of the spliceosome, interacting with its CDC5L component
  • BCAS2 directly interacts with each component of the PRPF19/CDC5L complex core
  • interacts with PHD3 via its C-terminal WD40 region, and the interaction is enhanced under hypoxic conditions through the utilization of the N-terminal coiled-coil domain
  • CTNNBL1 associated with PRPF19-containing RNA-splicing complexes as well as with the antibody-diversifying enzyme AICDA
  • SNW1-associated factors DHX8 and PRPF19 are also selectively required for CDKN1A expression under stress
  • EXOC7 interacts directly with PRPF19 and shuttles to the nucleus, where it associates with the spliceosome
  • DHX15 and PRPF19, two spliceosome components, are novel RBM5-interacting partner
  • CCDC94 and the PRPF9 complex protect cells from IR-induced apoptosis by repressing the expression of TP53 mRNA
  • PRPF19 complex is the first spliceosome subcomplex that directly contributes to mitosis in vertebrates independently of its function in interphase
  • BCAS2 and PRPF19 subunits of the PSO4 complex directly interact and colocalize with replication protein A (RPA1)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in various cell types during replicative senescence
    tumoral     --over  
    in various immortalized cell lines, as well as in breast tumors, with good survival
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS