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FLASH GENE
Symbol PROM2 contributors: mct - updated : 19-12-2023
HGNC name prominin 2
HGNC id 20685
Location 2q11.1      Physical location : 95.940.200 - 95.957.053
Synonym name
  • prominin-related protein
  • prominin-like protein 2
  • Synonym symbol(s) PROM-2, PROML2, MGC138714
    DNA
    TYPE functioning gene
    STRUCTURE 16.85 kb     24 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    24 - 3813 - 488 - 2019 31735663
    24 - 4731 - 834 - 2019 31735663
    24 - 3822 - 834 - 2019 31735663
    24 - 2922 - 834 - 2019 31735663
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Urinarykidney   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymhoid/ImmuneT cell null
    Nervousepithelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • five transmembrane segments
  • two large glycosylated extracellular loops
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • restricted to epithelial cells
  • basic FUNCTION
  • PROM1, PROM2 are pentaspan membrane proteins that bind cholesterol and localize to plasma membrane (PM) protrusions
  • PROM2 protrusions primarily localize to lipid rafts and recruit cholesterol into protrusions and away from caveolae, leading to increased phosphorylation of CAV1, which inhibits CDC42-dependent endocytosis
  • PROM1 and PROM2 expression differentially modulates the clinical outcomes of cancers
  • promotes the formation of ferritin-containing multivesicular bodies (MVBs) and exosomes that transport iron out of the cell, inhibiting ferroptosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PROM2 expression significantly decreased caveolae at the Plasma Membrane, reduced caveolar endocytosis and increased caveolin-1 phosphorylation
  • cell & other
    REGULATION
    induced by ferroptotic stimuli and functions to resist ferroptotic death
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    associated with poor overall survival in lung and ovarian cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • PROM2 overexpression is a potential diagnostic and prognostic biomarker of survival in breast cancer (BRCA), lung adenocarcinoma (LUAD), and uterine corpus endometrial carcinoma (UCEC) patients
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    targeting PROM2 transcription to overcome ferroptosis resistance in cancer
    ANIMAL & CELL MODELS
  • upregulation of Prom2 was detected in Prom1-deficient mice highlighting a potential compensatory mechanism, which might explain the lack of severe symptoms in individuals carrying mutations in the Prom1 gene