Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PROL1 contributors: - updated : 19-12-2006
HGNC name proline rich, lacrimal 1
HGNC id 17279
Location 4q13.2      Physical location : 71.263.598 - 71.275.910
Synonym name
  • basic proline-rich protein
  • basic proline-rich lacrimal protein
  • opiorphin
  • Synonym symbol(s) BPLP, PRL1
    DNA
    TYPE functioning gene
    STRUCTURE 12.00 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary glandsubmandibular   
    Visualeyelacrimal gland  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N-terminal putative peptide QRSFR processed by selective cleavage at consensus sites
  • a 21-AA secretory leader sequence
  • an N-glycosylation site
  • a zona pellucida (Zp) domain
  • HOMOLOGY
    interspecies homolog to rat sialorphin peptide
    Homologene
    FAMILY PROL1/PROL3 family
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may provide a protective function at the eye surface
  • displaying potent analgesic activity in chemical and mechanical pain models by activating endogenous opioid-dependent transmission
  • inhibitor of MME and ANPEP, acting as a natural antinociceptive modulator of opioid-dependent pathways
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with MME and ANPEP
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS