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FLASH GENE

Symbol

PROKR1

contributors: mct/npt - updated : 07-07-2020

HGNC name	prokineticin receptor 1
HGNC id	4524

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	2p13.3      Physical location : 68.872.953 - 68.882.706
Synonym name	G protein-coupled receptor 73
	G-protein coupled receptor ZAQ
Synonym symbol(s)	ZAQ, PKR1, GPR73a, PK-R1, GPR73,

DNA

TYPE	functioning gene
STRUCTURE	14.67 kb     2 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_138964 3 - 4287 NP_620414 44 393 - 2015 26574895

EXPRESSION

Type

widely

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive liver       lowly Endocrine pancreas       highly Nervous brain hindbrain medulla oblongata   lowly Reproductive female system placenta     highly Homo sapiens   male system testis       Respiratory lung       lowly Skin/Tegument skin         Urinary kidney       lowly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane segments

HOMOLOGY

interspecies

homolog to murine Gpr73

Homologene

FAMILY

G protein coupled receptor family 1

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule
text	PROKR1 was detected in primary cilia

basic FUNCTION	involved in G-protein coupled receptor protein signaling pathway
	(PROK1) signalling via prokineticin receptor 1 (PROKR1) regulates the expression of several genes with important roles in endometrial receptivity and implantation.
	PROKR1, but also PROKR2 might mediate a complementary signalling to the RET/GDNF pathway supporting proliferation/survival and differentiation of precursor cells during enteric nervous system (ENS) development

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

PROK1-PROKR1 signalling pathway regulating IL11

a component

INTERACTION

DNA

RNA

small molecule

protein	PROK1-PROKR1 interaction induced inositol phosphate mobilization and sequential phosphorylation of c-Src, epidermal growth factor receptor, and ERK 1/2 (Evans 2008)
	PROK2-induced the formation of vessel-like structures by aortic endothelial cells expressing only PROKR1, and disorganized the tight junctions in hepatic sinusoidal endothelial cells expressing only PROKR2, confirming the divergent roles of these receptors
	MRAP2 interacts with and inhibits the trafficking and signaling of the prokineticin receptor 1 (PROKR1)
	TBX20 is a novel transcription factor regulating angiogenesis through the PROK2-PROKR1 (prokineticin receptor 1) pathway in both development and disease
	PROK1 and PROK2 bind to two highly related G protein-coupled receptors (GPCRs), prokineticin receptor 1 (PROKR1) and prokineticin receptor 2 (PROKR2)
	PROK1, PROK2 increased blood-brain barrier (BBB) permeability, which could be prevented by PROKR1 and PROKR2 antagonists

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   PROK1 and PROKR1 expression is elevated in decidua during early pregnancy and that PROK1-PROKR1 interaction regulates expression of a host of implantation-related genes (Evans 2008)

Susceptibility

to recurrent miscarriage (RM)

Variant & Polymorphism other	PROKR1 (I379V) variant conferred lower risk for RM and may play protective roles in early pregnancy by altering calcium signaling and facilitating cell invasiveness

Candidate gene
Marker
Therapy target	may represent a novel therapeutic target to limit myocardial injury following ischemic events (Urayama 2007)

ANIMAL & CELL MODELS