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FLASH GENE
Symbol PROCR contributors: mct - updated : 29-11-2014
HGNC name protein C receptor, endothelial (EPCR)
HGNC id 9452
Location 20q11.22      Physical location : 33.759.773 - 33.765.164
Synonym name
  • endothelial protein C receptor
  • CD201 antigen receptor
  • activated protein C receptor
  • cell cycle, centrosome-associated protein
  • centrocyclin
    • Synonym symbol(s) CCD41, EPCR, CCCA
    DNA
    TYPE virus associated
    STRUCTURE 44.81 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (TATA box)
    Binding site
    text structure A1, SP1, AP2 binding sites
    MAPPING cloned Y linked N status provisional
    Map cen - D20S106 - PROCR - ASIP - RPN2 - RBL1 - D20S884 - D20S84 ,BPI - D20S174 - D20S107 - qter
    Authors GeneMap (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1506 - 238 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessels     Homo sapiens
    Digestiveliver   highly Mus musculusFetal
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connective    
    Epithelialbarrier/lining   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal signal sequence
  • extracellular domain with four potential N-glycosylation sites and four cysteine residues
  • C terminal transmembrane region and short cytoplasmic tail
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY member of the CD1/MHC superfamily
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    text membrane protein type 1
    basic FUNCTION
  • involved in the enhancement of protein C activation by the thrombin-thrombomodulin complex
  • PROCR -bound PROC might modulate F2R-mediated responses of smooth muscle cells (SMCs) to vascular injury
  • with endogenous protein C, is essential for the functional integrity of human endothelial cells
  • supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors
  • occupancy of PROCR by its natural ligand modulates the F2R-dependent signaling specificity of coagulation proteases
  • multi-ligand vitamin K-dependent protein receptor for zymogen and activated forms of plasma protein C and factor 7
  • can attenuate the growth of tissue factor-expressing tumor cells.
  • stem cell marker in hematopoietic, neuronal and epithelial cells, and crucial for breast cancer growth
  • plays an important role in coagulation and inflammation
  • plays a crucial role in the protein C anticoagulant pathway by promoting protein C activation
  • play a key role in mediating activated protein C (APC)-induced cytoprotective effects, including antiapoptotic, anti-inflammatory, and barrier stabilization
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS coagulation/hemostasis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PROC
  • is associated with CAV1 in lipid rafts of endothelial cells
  • F7 binds to the endothelial cell protein C receptor (PROCR) on the vascular endothelium, and F7 binding to PROCR on the endothelium facilitates the transport of F7 from circulation to extravascular tissues
  • SERPINE2 inhibits FURIN, a serine protease that activates MMP17 involved in the shedding of endothelial PROCR, suggesting a direct interaction between SERPINE2 and FURIN in endothelial cells
  • can be shed from the cell surface, and this is mediated by tumor necrosis factor-alpha-converting enzyme (ADAM17)
  • cellular receptor for protein C on endothelial cells
    • cell & other
    REGULATION
    repressed by Piperlonguminine
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    on brain vessels in malaria caused by cytoadherent infected erythrocytes, with localized coagulation, inflammation, and disruption of endothelial barrier function, leading to cerebral malaria
    Susceptibility to venous thromboembolism (VTE)
    Variant & Polymorphism other
  • allele A3 associated with elevated plasma PROCR level and venous thrombosis
  • protective role of PROCR H1 against venous thromboembolism (VTE) and an increased risk of VTE associated with the H3 haplotype
    • Candidate gene
    Marker
  • detection of soluble PROCR in cancer and during the post-treatment period could be taken into account as an additional marker that could re-inforce the one obtained using CA125 alone as a marker of cancer cell mass
    • Therapy target
    ANIMAL & CELL MODELS