protein
| heat shock protein 60, Hsp60 |
|
casein kinase 2, CK2 |
|
plasminogen |
|
neuronal phosphoprotein synapsin Ib, Grb2, and Pint1 |
|
stress-inducible protein 1, STI1 |
|
heparin |
|
tubulin |
|
heterogeneous nuclear ribonucleoprotein A2/B1 and aldolase C |
|
lipoprotein receptor-related protein 1, LRP1 |
|
clusterin |
|
Abeta42 oligomers |
|
ADAM23 |
|
STIP1 (PMID : |
|
kinesin and dynein |
|
Hsp70 |
|
thiamine |
|
KCTD1 is a molecular interaction partners of the cellular prion protein (PRNP) |
|
ADAM8 can perform alpha-cleavage of PRNP and PRNP can regulate ADAM8 expression |
|
amyloid-beta precursor protein |
|
FOXO3 negatively regulates PRNP expression by binding to the PRNP promoter, which is negatively regulated by insulin-like growth factor 1 (IGF1) |
|
interacts with BECN1 to recruit the PIK3C3 complex into lipid rafts and thus activates autophagy in response to Abeta42, defining a novel role of PRNP in the regulation of autophagy |
|
AMFR is critical for unglycosylated PRNP ubiquitylation and degradation |
| mice expressing DeltaPrP or Dpl suffer from widespread leukoencephalopathy | |
mouse expressing the PrP(DeltaCD), a PrP variant lacking 40 central residues, displays a rapidly progressive, lethal phenotype with extensive central and peripheral myelin degeneration |
|
ablation of the prion protein PrP(C) triggers a chronic demyelinating polyneuropathy in four independently targeted mouse strains |
|
absence of PrPC in a transgenic Alzheimer mouse rescues deficits in spatial learning and memory |
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Knockdown PRNP homolog in the zebrafish leads to a dose-dependent phenotype characterized by systemic morphological defects, reduced cell adhesion and CNS cell death |