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FLASH GENE

Symbol

PRMT8

contributors: mlc/npt - updated : 23-03-2007

HGNC name	protein arginine methyltransferase 8
HGNC id	5188

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12p13.3      Physical location : 3.600.424 - 3.703.136
Synonym name	HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 3
	protein arginine N-methyltransferase 4
	HMT1 hnRNP methyltransferase-like 3 (S. cerevisiae)
	protein arginine N-methyltransferase 8
	heterogeneous nuclear ribonucleoprotein
Synonym symbol(s)	HRMT1L3, HRMT1L4
EC.number	2.1.1.26

DNA

TYPE	functioning gene
STRUCTURE	102.00 kb     10 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed PRMT8 10 - 2356 45 394 - -

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       highly Reproductive male system testis       Respiratory lung         Visual eye

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	unique N-terminal end harboring a myristoylation motif
	two proline-rich sequences that are predicted to bind SH3 domains, that may function as an autoregulator and may be displaced by interaction with one or more physiological inducers (acting in a regulatory fashion in the autoinhibition of the c-Abl kinase)

HOMOLOGY

interspecies

ortholog to murine Prmt8

intraspecies	homolog to HRMT1L2
	homolog to PRMT1 (80 p100)

Homologene

FAMILY

arginine N methyl-transferase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,nucleus
text	localized to the plasma membrane by N-terminal myristoylation

basic FUNCTION

arginine methyltransferase transferring a methyl group from S adenosylmethionine to the guanidino group nitrogen atoms of specific proteins

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

aminoacid

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

binding to the hnRNP (heterogeneous nucleoribonucleo proteins)

cell & other

REGULATION

Other

modified by the attachment of a myristate to the glycine residue after the initiator methionine; the myristoylation results in its association with the plasma membrane

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS