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FLASH GENE

Symbol

PRMT7

contributors: KTN/npt - updated : 22/09/2008

HGNC name	protein arginine methyltransferase 7
HGNC id	25557

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	16q22.1      Physical location : 68.344.876 - 68.391.168
Synonym symbol(s)	FLJ10640, KIAA1933
EC.number	2.1.1.-

DNA

TYPE	functioning gene
STRUCTURE	46.20 kb     19 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed PRMT7 19 splicing 2390 78.3 692 - Verbiest

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel       highly Digestive intestine small intestine     highly Lymphoid/Immune spleen       highly   thymus       predominantly Reproductive male system prostate     moderately Respiratory respiratory tract larynx     moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     moderately

cell lineage
cell lines
fluid/secretion	moderately in blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a C2H2-type zinc finger domain
	two putative AdoMet-binding motifs

mono polymer

homomer , monomer , dimer

HOMOLOGY

interspecies	homolog to Dog PRMT7 (88.1 pc)
	homolog to chimpanzee PRMT7 (96.8 pc)
	homolog to cow PRMT7 (87.7 pc)
	homolog to rattus Prmt7 (84.3 pc)
	homolog to murine Prmt7 (85.4 pc)

Homologene

FAMILY

protein arginine N-methyltransferase family

CATEGORY

enzyme , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,nucleus

basic FUNCTION	methylating (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins
	catalyzing the formation of omega-NG-monomethylarginine in peptides
	type II methyltransferase capable of producing symmetric dimethylarginine modifications in proteins

CELLULAR PROCESS

nucleotide, chromatin organization, methylation

PHYSIOLOGICAL PROCESS

text	histone methylation

PATHWAY

metabolism

aminoacid

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS