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FLASH GENE
Symbol PRMT2 contributors: mct/npt/pgu - updated : 17-04-2015
HGNC name protein arginine methyltransferase 2
HGNC id 5186
Location 21q22.3      Physical location : 48.055.526 - 48.084.862
Synonym name
  • HMT1 hnRNP methyltransferase-like 1 (S. cerevisiae)
  • protein arginine N methyltransferase 2
    • Synonym symbol(s) HRMT1L1, MGC111373, HMT1
    EC.number 2.1.1.24, 2.1.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 29.65 kb     11 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    text Variants 1 and 2 encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 2552 49 433 - 2011 21820040
    11 - 2443 49 433 - 2011 21820040
    - polyA site - - - - 2011 21820040
  • PRMT2 and PRMT2L2 mRNA expressions were up-regulated in breast cancer tissues, and significantly associated with ESR1 positivity status
  • enhance ESR1-mediated transactivation activity in a ligand-dependent manner
    • 9 - 2137 37.2 331 - 2011 21820040
    7 - 2300 31.2 277 - 2011 21820040
    7 - 4438 - 284 - 2011 21820040
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestivesalivary gland   highly
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text cell tissues
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • SRC homology 3 domain in the N terminal region
  • the alternatively spliced C-terminus of PRMT2 can directly influence its subcellular localization
    • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae MMT1 like 1
    Homologene
    FAMILY
  • protein arginine N methyltransferase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text in the presence of androgens with AR colocalize and translocate into the nucleus
    basic FUNCTION
  • arginine methyltransferase transferring a methyl group from S adenosyl methionine to the guanidino group nitrogen atoms of specific proteins
  • acts as AR-coactivator, presumably by arginine methylation
  • coactivator of estrogen receptor alpha
  • new member of the NFKB1 pathway controlling LPS-induced inflammatory and lung responses in a dosage-dependent manner
  • PRMT2 and its splice variants may directly modulate ESR1 signaling and play a role in the progression of breast cancer
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
  • S-adenosylmethionine dependent
    • protein
  • enhancing ESR1
  • also binding ESR2, PR, TRbeta, RAR alpha, PPAR gamma, RXR alpha
  • interacting with the coactivators NCOA1 and NCOA6
  • acting as a strong coactivator of the AR, had modest or none influence on transcriptional activation mediated by other nuclear receptors
  • binding to hnRNP (heterogeneous nuclear riboproteins)
  • PRMT1 serves as the major methyltransferase in cells by forming higher-order oligomers with itself, PRMT2, and possibly other PRMTs
  • COBL-mediated dendritic arborization required PRMT2, complex formation with PRMT2, and PRMT2 catalytic activity (pMID: 29689199)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene for dyslexia
    Marker
    Therapy target
    ANIMAL & CELL MODELS