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FLASH GENE
Symbol PRM2 contributors: mct/npt - updated : 17-07-2008
HGNC name protamine 2
HGNC id 9448
Location 16p13.13      Physical location : 11.369.492 - 11.370.337
Synonym name
  • sperm protamine P2
  • sperm histone HP4, HP2, HP3
  • Synonym symbol(s) FLJ27447
    DNA
    TYPE functioning gene
    STRUCTURE 0.84 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (TATA box)
    text structure 5′ flanking regions contain putative TATA boxes and cAMP-response elements (CREs), but the TATA boxes and CREs exhibit gene-specific sequences, and an overwhelming majority of CREs differ from the consensus sequence
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 683 13 102 - Hammoud (2007)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    Reproductivemale systemtestis   
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion spermatid specific
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Prm2
    homolog to C.elegans B0310.4
    Homologene
    FAMILY
  • protamine P2 family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome,nucleosome
    text nucleosome
    basic FUNCTION
  • substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis
  • basic chromosomal protein that replace the histones during chromatin remodeling
  • during mammalian spermatogenesis, involved in the substantial condensation of the chromatin structure (Kempisty 2007)
  • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    PHYSIOLOGICAL PROCESS reproduction/sex
    text
  • spermatogenesis
  • mitotic chromosome condensation (DNA packaging)
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    reduction in contents of PRM1 and PRM2 transcripts in spermatozoa may be linked with asthenozoospermia (Kempisty 2007)
    Susceptibility to male infertility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS