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FLASH GENE
Symbol PRM1 contributors: mct/npt - updated : 19-10-2009
HGNC name protamine 1
HGNC id 9447
Location 16p13.13      Physical location : 11.374.693 - 11.375.192
Synonym name
  • sperm protamine P1
  • cancer/testis antigen family 94, member 1
  • cysteine-rich protamine
  • Synonym symbol(s) HSP1, CT94.1
    DNA
    TYPE functioning gene
    STRUCTURE 0.50 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (TATA box)
    text structure 5prime flanking regions contain putative TATA boxes and cAMP-response elements (CREs), but the TATA boxes and CREs exhibit gene-specific sequences, and an overwhelming majority of CREs differ from the consensus sequence
    MAPPING cloned Y linked Y status confirmed
    Map pter - 5' - PRM1 - PRM2 - TNP2 - SOCS1 - 3' - cen
    Authors Engel (92), Kramer (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 426 - 51 - Li (2008)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainhindbrainmedulla oblongata  
    Reproductivemale systemtestis   
    cell lineage
    cell lines
    fluid/secretion spermatid specific
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • protamine P1 family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome,nucleosome
    basic FUNCTION
  • substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis
  • involved in mitotic chromosome condensation
  • basic chromosomal protein that replace the histones during chromatin remodeling
  • during mammalian spermatogenesis, involved in the substantial condensation of the chromatin structure (Kempisty 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    reduction in contents of PRM1 and PRM2 transcripts in spermatozoa may be linked with asthenozoospermia (Kempisty 2007)
    Susceptibility to male infertility
    Variant & Polymorphism other c.-107G>C change that is located at -15 bp from the transcription initiation site, detected in oligozoospermia (Ravel 2007)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS