basic FUNCTION
| prolactin receptor activity |
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reducing the lipoprotein lipase activity by prolactin binding |
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can positively or negatively activate PRL transcription by heterodimerizing |
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inducing lactation by GH binding |
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role of the prolactin receptor in parathyroid adenomas |
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PRLR signaling complex has been implicated in the pathology of breast and prostate carcinoma |
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may have a role in bone/cartilage formation/repair processes |
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novel function for hepatic PRLR in the regulation of insulin sensitivity |
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PRLR, acting within the pancreas, mediates maternal pancreatic adaptations to pregnancy and therefore its dysfunction may increase a woman's chances of becoming glucose intolerant during pregnancy |
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is a hormone that is mainly synthesized and secreted by lactotroph cells in the anterior pituitary gland |
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involvement in metabolic homeostasis including body weight control, adipose tissue, skin and hair follicles, pancreas, bone, the adrenal response to stress, the control of lactotroph cell homeostasis and maternal behaviour |