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FLASH GENE
Symbol PRLR contributors: mct/npt - updated : 27/10/2008
HGNC name prolactin receptor
HGNC id 9446
Location 5p14-p13.2      Physical location : 35.055.801 - 35.230.794
Synonym name
  • delta 4-delta 7/11 truncated prolactin receptor
  • secreted prolactin binding protein
  • Synonym symbol(s) PRL-R, hPRLrI
    DNA
    TYPE functioning gene
    STRUCTURE 166.35 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    alternative promoter
    Binding site
    text structure two alternative promoters hpIII, hp5n, eight coding exons 3-10, SP1 C/EBP element (first promoter)
    MAPPING cloned Y linked N status provisional
    Physical map
    PC4 5p13.3 activated RNA polymerase II transcription cofactor 4 NPR3 5p14-p13 natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) FLJ14054 5p13.3 hypothetical protein FLJ14054 LOC389278 5 similar to 40S ribosomal protein S8 TARS 5p13.3-p13.2 threonyl-tRNA synthetase LOC389279 5 similar to RPE-spondin LOC391776 5 similar to Probable mitochondrial import receptor subunit TOM40 homolog (Translocase of outer membrane 40 kDa subunit homolog) (Haymaker protein) (p38.5) ADAMTS12 5q35 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12 SALPR 5p15.1-p14 G-protein coupled receptor SALPR MATP 5p13.3 membrane associated transporter protein AMACR 5p13.3-p12 alpha-methylacyl-CoA racemase C1QTNF3 5p13-p12 C1q and tumor necrosis factor related protein 3 LOC389280 5 similar to SMA3 protein LOC389281 5 similar to bA110H4.2 (similar to membrane protein) RAI14 5p13.3-p13.2 retinoic acid induced 14 FLJ25439 5p13.3 hypothetical protein FLJ25439 RAD1 5p13.3-p13.2 RAD1 homolog (S. pombe) BRIX 5p13.3 BRIX LOC134218 5p13.3 hypothetical protein LOC134218 AGXT2 5p13 alanine-glyoxylate aminotransferase 2 PRLR 5p14-p13.3 prolactin receptor LOC389282 5 similar to RIKEN cDNA C230086A09 gene FLJ23577 5p13.2 hypothetical protein FLJ23577 IL7R 5p13 interleukin 7 receptor MGC26610 5p13.2 hypothetical protein MGC26610 FLJ34658 5p13.2 hypothetical protein FLJ34658 LOC167127 5p13.2 hypothetical protein LOC167127 DKFZp434H2226 5p13.2 hypothetical protein DKFZp434H2226 SKP2 5p13 S-phase kinase-associated protein 2 (p45) FLJ30596 5p13.2 hypothetical protein FLJ30596 FLJ25422 5p13.2 hypothetical protein FLJ25422 SLC1A3 5p13 solute carrier family 1 (glial high affinity glutamate transporter), member 3 LOC345513 5p13.2 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) IDN3 5p13.2 IDN3 protein LOC391777 5 similar to ribosomal protein S4, X-linked FLJ13231 5p13.2 hypothetical protein FLJ13231 LOC389283 5 LOC389283 OFD1P1 5p13 oral-facial-digital syndrome 1, pseudogene 1 NUP155 5p13 nucleoporin 155kDa FLJ10233 5p13.2 hypothetical protein FLJ10233
    RNA
    TRANSCRIPTS type messenger
    text five PRLR isoforms (L, I, S1a, S1b, S1d) in abdominal and breast adipose tissues (Ling 2003)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 856 - - predominant in colon, liver, stomach and placenta Ling et al. 2003
    - splicing 284 - - predominant in bone marrow, heart, small intestine, spleen, skeletal muscle Ling et al. 2003
    - splicing 460 39 - - Ling et al. 2003
    - splicing 306 29 - - Ling et al. 2003
    - splicing 1566 70 521 widely Kline
    activating the proximal signaling molecule JAK2 upon addition of ligand to transfected cells, and, unlike the long PRLr
    10 - 11794 - 622 - Bogorad (2008)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Reproductivefemale systembreastmammary gland highly
     female systemplacenta  highly
     male systemtestis  highly Homo sapiens
     ovary    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatozoa Homo sapiens
    cell lineage
    cell lines breast cancer
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two fibronectin type III domains
  • HOMOLOGY
    Homologene
    FAMILY
  • cytokine receptor family
  • CATEGORY signaling hormone , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • prolactin receptor activity
  • reducing the lipoprotein lipase activity by prolactin binding
  • can positively or negatively activate PRL transcription by heterodimerizing
  • inducing lactation by GH binding
  • may have a role in bone/cartilage formation/repair processes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to PRL, GH
  • interacting with cyclophilin A
  • cell & other
    REGULATION
    induced by estradiol in breast cancer cells
    Other regulated by phosphorylation on Thr391
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation     gain of function
    in benign breast tumors
    Susceptibility to breast cancer
    Variant & Polymorphism other A150C (leu->ile) transversion at exon 6, polymorphism that might play a role in mammary carcinogenesis
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS