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FLASH GENE
Symbol PRKRIR contributors: mct - updated : 30-08-2012
HGNC name protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
HGNC id 9440
Location 11q13.5      Physical location : 76.061.003 - 76.091.880
Synonym name
  • inhibitor of protein kinase PKR
  • death -associated protein 4
  • Synonym symbol(s) P52RIPK, DAP4, THAP0,
    DNA
    TYPE functioning gene
    STRUCTURE 30.88 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    HCP27 11q13.3 cytochrome c, somatic pseudogene LOC387787 11 similar to RIKEN cDNA 2610209A20 POLD3 11q14 similar to RIKEN cDNA 2610209A20 BNF1 FLJ22596 11q13.3 hypothetical protein FLJ22596 LOC387788 11 similar to ribosomal protein S12 KIAA1991 11q13.3 hypothetical protein KIAA1991 KIAA0102 11q13.3 hypothetical protein KIAA1991 LOC387789 11 LOC387789 NEU3 11q13.5 sialidase 3 (membrane sialidase) LOC390224 11 similar to olfactory receptor MOR101-2 LOC341152 11q13.3 similar to olfactory receptor MOR101-1 LOC390225 11 similar to olfactory receptor MOR101-2 SLCO2B1 11q13 solute carrier organic anion transporter family, member 2B1 ARRB1 11q13 arrestin, beta 1 RPS3 11q13.3-q13.5 ribosomal protein S3 FLJ33790 11q13.3 hypothetical protein FLJ33790 PP1665 11q13.3 hypothetical protein PP1665 SERPINH1 11q13.5 serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) MAP6 6p12-p11 microtubule-associated protein 6 MGAT2 14q21 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase DGAT2 11q13.3 diacylglycerol O-acyltransferase homolog 2 (mouse) UVRAG 11q13 UV radiation resistance associated gene WNT11 11q13.5 wingless-type MMTV integration site family, member 11 PRKRIR 11q13.5 protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) LOC387790 11 LOC387790 C11orf30 11q13.5 chromosome 11 open reading frame 30 GARP 11q13.5-q14 glycoprotein A repetitions predominant LOC390226 11 similar to Olfactory guanylyl cyclase GC-D precursor (Guanylate cyclase, olfactory) E2IG4 11q13.3 hypothetical protein, estradiol-induced PHCA 11q13.4 phytoceramidase, alkaline IMAGE:4907098 11q13.4 beta-1,3-N-acetylglucosaminyltransferase protein CAPN5 11q14 calpain 5 OMP 11q13 olfactory marker protein MYO7A 11q13.5 myosin VIIA (Usher syndrome 1B (autosomal recessive, severe)) LOC220032 11q13.4 GDPD domain containing protein LOC387791 11 similar to Mitochondrial import receptor subunit TOM20 homolog (Mitochondrial 20 kDa outer membrane protein) (Outer mitochondrial membrane receptor Tom20) PAK1 11q13.5-q14.1 p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) LOC387792 11 LOC387792 AQP11 11q13.4 aquaporin 11 CLNS1A 11q13.5-q14.1 chloride channel, nucleotide-sensitive, 1A HBXAP 11q13.4-q14.1 hepatitis B virus x associated protein PTD015 11q13.4 PTD015 protein MGC16733 11q13.4 hypothetical gene MGC16733 similar to CG12113 KCTD14 11q13.4 potassium channel tetramerisation domain containing 14
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 3202 52 761 - 2011 21910972
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinesmall intestine  highly
    Reproductivefemale systemovary  highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a THAP domain, a zinc-dependent sequence-specific DNA-binding domain belonging to the zinc-finger superfamily
  • C-terminal domain required for physical interaction and the signal augmentation
  • HOMOLOGY
    intraspecies homolog to HSP (90kDa)
    Homologene
    FAMILY PRK family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • protein kinase,double stranded RNA dependent inhibitor,particularly of P58
  • may function as zinc-dependent sequence-specific DNA-binding factors with roles in proliferation, apoptosis, cell cycle, chromosome segregation, chromatin modification, and transcriptional
  • synergistically enhances type I IFN production mediated by a signal activated- or constitutively active form of regulation of DDX58
  • novel positive regulator controlling the DDX58-IFN production system through protein stability control
  • inhibits ubiquitination of DDX58 and suppresses proteasomal degradation of DDX58 proteins, thereby enhancing DDX58-mediated signaling pathways for IFNB synthesis
  • novel positive regulator of DDX58-mediated antiviral signaling pathways
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DDX58 interacting protein (DDX58 interacts through the C-terminal domain of PRKRIR, and the N-terminal region of PRKRIR potentially possesses inhibitory functions to block DDX58 interaction)
  • selectively acts on the DDX58-mediated IRF3 activation and type I IFN synthesis, but not IFIH1
  • cell & other
    REGULATION
    induced by interferon-inducible
    in the virus-infected cells through NLRC5 activation, and controlling the activity of the antiviral protein PKR
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS