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FLASH GENE
Symbol PRKRIR contributors: mct - updated : 30-08-2012
HGNC name protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
HGNC id 9440
Location 11q13.5      Physical location : 76.061.003 - 76.091.880
Synonym name
  • inhibitor of protein kinase PKR
  • death -associated protein 4
  • Synonym symbol(s) P52RIPK, DAP4, THAP0,
    DNA
    TYPE functioning gene
    STRUCTURE 30.88 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 3202 52 761 - 2011 21910972
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinesmall intestine  highly
    Reproductivefemale systemovary  highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a THAP domain, a zinc-dependent sequence-specific DNA-binding domain belonging to the zinc-finger superfamily
  • C-terminal domain required for physical interaction and the signal augmentation
  • HOMOLOGY
    intraspecies homolog to HSP (90kDa)
    Homologene
    FAMILY PRK family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • protein kinase,double stranded RNA dependent inhibitor,particularly of P58
  • may function as zinc-dependent sequence-specific DNA-binding factors with roles in proliferation, apoptosis, cell cycle, chromosome segregation, chromatin modification, and transcriptional
  • synergistically enhances type I IFN production mediated by a signal activated- or constitutively active form of regulation of DDX58
  • novel positive regulator controlling the DDX58-IFN production system through protein stability control
  • inhibits ubiquitination of DDX58 and suppresses proteasomal degradation of DDX58 proteins, thereby enhancing DDX58-mediated signaling pathways for IFNB synthesis
  • novel positive regulator of DDX58-mediated antiviral signaling pathways
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DDX58 interacting protein (DDX58 interacts through the C-terminal domain of PRKRIR, and the N-terminal region of PRKRIR potentially possesses inhibitory functions to block DDX58 interaction)
  • selectively acts on the DDX58-mediated IRF3 activation and type I IFN synthesis, but not IFIH1
  • cell & other
    REGULATION
    induced by interferon-inducible
    in the virus-infected cells through NLRC5 activation, and controlling the activity of the antiviral protein PKR
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS