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FLASH GENE
Symbol PRKRIP1 contributors: mct - updated : 09-07-2021
HGNC name PRKR interacting protein 1 (IL11 inducible)
HGNC id 21894
Location 7q22.1      Physical location : 102.036.803 - 102.067.129
Synonym name
  • likely ortholog of mouse C114 dsRNA-binding protein
  • KRAB box domain containing 3
  • Synonym symbol(s) C114, FLJ13902, FLJ40957, KRBOX3
    DNA
    TYPE functioning gene
    STRUCTURE 30.30 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2159 20.9 184 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvesselaorta   
    Reproductivefemale systemuterus   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    secondary structure
  • forms a 100- alpha helix linking the distant U2 snRNP to the catalytic center
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Prkrip1 (92.4 pc)
    homolog to rattus Prkrip1 (92.9 pc)
    Homologene
    FAMILY
  • PRKRIP1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • inhibiting EIF2AK2 kinase activity
  • may play a role in cytokine-mediated biological functions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding double-stranded RNA
    small molecule
    protein
  • interacting with EIF2AK2
  • cell & other
    REGULATION
    induced by IL-11
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    miscelleaneousurinarychronic kidney disease
    PRKRIP1 is a novel targets for autoantibodies in chronic renal disease (PMID: 21183621)
    ANIMAL & CELL MODELS