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FLASH GENE
Symbol PRKRIP1 contributors: KTN/npt - updated : 12-01-2009
HGNC name PRKR interacting protein 1 (IL11 inducible)
HGNC id 21894
Location 7q22.1      Physical location : 102.036.803 - 102.067.129
Synonym name likely ortholog of mouse C114 dsRNA-binding protein
Synonym symbol(s) C114, FLJ13902, FLJ40957
DNA
TYPE functioning gene
STRUCTURE 30.33 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
PLOD3 7q36 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 ZNHIT1 7q22.1 zinc finger, HIT domain containing 1 CLDN15 7q22 claudin 15 TTC11 7q22.1 tetratricopeptide repeat domain 11 LOC392082 7 similar to Zn-alpha-2-glycoprotein precursor FLJ14117 COL26A1 7q22.1 collagen, type XXVI, alpha 1 MYLC2PL 7q22.1 myosin light chain 2, precursor lymphocyte-specific CUTL1 7q22 cut-like 1, CCAAT displacement protein (Drosophila) APS 7q22 adaptor protein with pleckstrin homology and src homology 2 domains LOC392083 7 similar to Cohesin subunit SA-3 (Stromal antigen 3) (SCC3 homolog 3) LOC389542 7 similar to Williams-Beuren syndrome critical region protein 19 LOC389543 7 similar to postmeiotic segregation increased 2-like 9 LOC392084 7 similar to Cohesin subunit SA-3 (Stromal antigen 3) (SCC3 homolog 3) PRKRIP1 7q22.1 PRKR interacting protein 1 (IL11 inducible) C7orf19 7q22.1 chromosome 7 open reading frame 19 FLJ20013 7q22.1 hypothetical protein FLJ20013 DKFZp434K1815 7q22.1 hypothetical protein DKFZp434K1815 POLR2J 7q11.2 polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa HSPC047 7q22.1 HSPC047 protein RASA4 7q22-q31.1 RAS p21 protein activator 4 POLR2J2 7q11.22 polymerase (RNA) II (DNA directed) polypeptide J, related gene MGC35361 7q22.1 hypothetical protein MGC35361 MGC21636 LRRC17 7q22 leucine rich repeat containing 17 SVH 7q22.1 SVH protein NAPE-PLD 7q22.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D LOC392085 7 similar to 60S ribosomal protein L23a FLJ36166 7q22.1 hypothetical protein FLJ36166 LOC392086 7 similar to Putative S100 calcium-binding protein A11 pseudogene LOC389544 7 similar to hypothetical protein FLJ32949 PMPCB 7q21.3-q22.1 peptidase (mitochondrial processing) beta ZRF1 7q22.1-q22.3 zuotin related factor 1 PSMC2 7q22.1-q22.3 proteasome (prosome, macropain) 26S subunit, ATPase, 2 PRES 7q22.1 prestin (motor protein)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 2181 20.9 184 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvesselaorta   
Reproductivefemale systemuterus   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated PhosphoP
HOMOLOGY
interspecies homolog to murine Prkrip1 (92.4 pc)
homolog to dog PRKRIP1 (92.9 pc)
homolog to chimpanzee PRKRIP1 (97.6 pc)
homolog to cow PRKRIP1 (90.8 pc)
homolog to rattus Prkrip1 (92.9 pc)
Homologene
FAMILY
  • PRKRIP1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • inhibiting EIF2AK2 kinase activity
  • may play a role in cytokine-mediated biological functions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding double-stranded RNA
    small molecule
    protein
  • interacting with EIF2AK2
  • cell & other
    REGULATION
    induced by IL-11
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS