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FLASH GENE
Symbol PRKRA contributors: npt/ - updated : 13-06-2007
HGNC name protein kinase, interferon-inducible double stranded RNA dependent activator
HGNC id 9438
Corresponding disease
DYT16 dystonia 16
Location 2q31.2      Physical location : 179.296.141 - 179.315.958
Synonym name
  • protein activator of the interferon-induced protein kinase
  • p53-associated cellular protein-testes derived
  • PKR-associating protein X
  • Synonym symbol(s) RAX, PACT, HSD14, P2P-R, RBBP6
    DNA
    TYPE functioning gene
    STRUCTURE 19.82 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   transcription factor
    text structure Specificity protein 1 (Sp1) is the major transcription factor responsible for PACT promoter activity
    MAPPING cloned Y linked N status tentative : very preliminary evidence
    Physical map
    HOXD4 2q31 homeo box D4 HOXD3 2q31 homeo box D3 HOXD1 2q31-q37 homeo box D1 LOC150978 2q31.2 similar to 60S acidic ribosomal protein P1 LOC129841 2q31.2 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) MTX2 2q24.3-q31 metaxin 2 LOC375295 2q31.2 hypothetical gene supported by BC013438 FUCA1P 2q31-q32 fucosidase, alpha-L- 1, tissue pseudogene LOC391465 2 similar to STIP1 homology and U-Box containing protein 1; serologically defined colon cancer antigen 7; carboxy terminus of Hsp70p-interacting protein; heat shock protein A binding protein 2 (c-terminal) LOC150739 2q31.2 similar to keratin 8; cytokeratin 8; keratin, type II cytoskeletal 8 hnRNPA3 2q31.2 heterogeneous nuclear ribonucleoprotein A3 NFE2L2 2q31 nuclear factor (erythroid-derived 2)-like 2 DKFZp451M2119 2q31.2-q31.3 hypothetical protein DKFZp451M2119 AGPS 2q33 alkylglycerone phosphate synthase FLJ30990 2q31.3 hypothetical protein FLJ30990 FLJ13946 2q31.3 hypothetical protein FLJ13946 PDE11A 2q31 phosphodiesterase 11A HCP9 2q31.2 cytochrome c, somatic pseudogene DRB1 2q31.3 developmentally regulated RNA-binding protein 1 OSBPL6 2q31-q32.1 oxysterol binding protein-like 6 PRKRA 2q31.2 protein kinase, interferon-inducible double stranded RNA dependent activator NUDCP2 2q31 nuclear distribution gene C homolog (A. nidulans) pseudogene 2 FKBP7 2q31.2 FK506 binding protein 7 PLEKHA3 2q31.2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 TTN 2q24.3-q31 titin FLJ39502 2q31.3 hypothetical protein FLJ39502 DKFZp434O0515 FLJ25270 LOC389065 2 similar to RIKEN cDNA B830010L13 gene LOC391466 2 similar to dim1 KIAA1604 2q32.1 KIAA1604 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1906 - 302 - -
    8 - 1826 - 313 - -
    8 - 1627 - 288 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrineneuroendocrinepituitary  highly
     pancreas    
    Nervousbrain    
    Reproductivemale systemprostate  lowly
     male systemtestis  highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , dimer , trimer
    HOMOLOGY
    interspecies homolog to murine Prkra
    Homologene
    FAMILY
  • PRKRA family
  • CATEGORY immunity/defense , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • activating PRKR which is an interferon -induced protein and mediates the antiviral effect of the interferons
  • involved in the negative regulation of TP53 function through ubiquitin-dependent proteolysis and playing a critical role in development
  • stress-modulated, cellular activator of interferon (IFN)-induced double-stranded RNA-activated protein kinase (PKR) and is an important regulator of PKR-dependent signaling pathways
  • facilitating the production of small interfering RNA (siRNA) by Dicer
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text negative control of cell proliferation immune response
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • heterodimerizing with PRKR
  • forming a triple complex with DICER and TARBP2
  • INTERACTION
    DNA
    RNA binding to double stranded RNA
    small molecule
    protein
  • binding and activating the interferon induced protein PRKR
  • ring finger-containing protein that can directly bind to TP53 (interaction playing a critical role in embryonic development and tumorigenesis )
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DYT16
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in esophageal cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS