protein
| binding and activating the interferon induced protein PRKR |
|
ring finger-containing protein that can directly bind to TP53 (interaction playing a critical role in embryonic development and tumorigenesis) |
|
AGO2, PRKRA and TARBP2 were required for the efficient functioning of DICER1 in cells, and likely one of the roles of these proteins is to assure better synchronization of cleavages triggered by two RNase III domains of DICER1 |
|
EIF2AK2 activation by PRKRA leads to phosphorylation of translation initiation factor EIF2A, inhibition of protein synthesis, and apoptosis |
|
PRKRA and TARBP2 have distinct effects on DICER1-mediated dsRNA processing |
|
PRKRA contributes to EIF2AK2 dephosphorylation during HIV-1 replication |
|
interface residues conserved between TARBP2 and PRKRA show that the proteins bind to DICER1 in a similar manner and by mutual exclusion |
|
stress-induced phosphorylation of PRKRA is essential for PRKRA association with EIF2AK2 leading to EIF2AK2 activation |
|
unexpected function for PRKRA as a negative regulator of EIF2AK2 in the context of postnatal anterior pituitary tissue, and critical role for the regulation of EIF2AK2 activity for normal development |
|
DDX3X may participate in antiviral innate immunity, at least in part, by translational control of PRKRA |