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FLASH GENE
Symbol PRKD3 contributors: mct/npt - updated : 13-12-2017
HGNC name protein kinase D3
HGNC id 9408
Location 2p22.2      Physical location : 37.477.647 - 37.544.222
Synonym name
  • protein kinase C, nu
  • protein kinase EPK2
  • protein-serine/threonine kinase
  • Synonym symbol(s) PKC-NU, EPK2, PRKCN, nPKC-NU, PKD3
    EC.number 2.7.11.13
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 66.58 kb     18 Exon(s)
    MAPPING cloned Y linked   status provisional
    Map pter - D2S2186 - D2S1925 - PRKD3 - D2S1501E - D2S2163 - cen
    Authors UCSC (2009)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 5907 - 890 - Lu (2007)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid   highly
    Lymphoid/Immunelymph node   highly
    Reproductivefemale systemuterus  highly
    Skin/Tegumentskin   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C-terminal region which contains its catalytic domain, is necessary but not sufficient for its nuclear localization (Rey 2006)
  • HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • PKD family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,vesicle
    text in vesicular structures
    basic FUNCTION
  • having a function in promoting its nuclear entry and the catalytic activity may potentially regulate its nuclear import through autophosphorylation and/or interaction with another protein (Rey 2006)
  • regulates protein transport from the Golgi to the plasma membrane and may regulate VAMP2 vesicle trafficking by facilitating its recruitment to the target membrane( Lu 2007)
  • plays a role in numerous processes including cell proliferation, cell survival, immune cell signaling, gene expression, vesicle trafficking, and neuronal development (Kunkel 2009)
  • PRKD3 regulates a distinct set of substrates to fulfill such functions, which is in accordance with our findings that PRKD3 selectively phosphorylates GIT1 to enhance cell spreading and motility
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly interacted with VAMP2 and colocalized in part with VAMP2 vesicles in cells
  • cellular activity of GIT1 via serine 46 phosphorylation is exclusively regulated by PRKD3, thus identifying GIT1 as the first specific substrate of PRKD3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS