| basic FUNCTION
| phorbolester and growth factor stimulated protein kinase |
|
implicated in the regulation of constitutive secretion in epithelial cells |
|
controls the release of secretory granules in neuroendocrine tumour cells at the level of the Golgi apparatus |
|
having a role in the proliferation and invasion of carcinoid tumors |
|
having a role in controlling phorbol ester binding, catalytic activity, and nucleocytoplasmic shuttling |
|
plays a role in numerous processes including cell proliferation, cell survival, immune cell signaling, gene expression, vesicle trafficking, and neuronal development  |
|
unlike PRKD1, PRKD2 catalytic activity is dispensable for normal embryogenesis |
|
PRKD2 catalytic activity is, however, required for efficient antigen receptor-induced cytokine production in T-lymphocytes and for optimal T-cell-dependent antibody responses |
|
a key role for PRKD2 in regulating the function of mature peripheral lymphocytes during adaptive immune responses |
|
key signaling enzyme that mediate a range of physiologically important cellular responses |
|
is a common signaling target downstream of various agonist receptors in platelets and G(q)-mediated signals along with calcium and novel PKC isoforms, in particular, PRKCD activate PRKD2 in platelets |
|
novel role of RPKD1, PRKD2 as a regulator of RHOA activity and actin stress fiber formation through phosphorylation of rhotekin |
|
has a restricted but critical role in T-cell antigen receptor signalling in mature T-cells |
|
is involved in the regulation of PP2A activity in activated T cells through phosphorylation of Ser171 of SET |
|
PRKD2 is a mediator of BCR-ABL transformation in chronic myelogenous leukemia |
|
is essential for hypoxia-induced accumulation of HIF1A and activation of NFKB1 in tumor cells |
