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FLASH GENE
Symbol PRKD2 contributors: mct - updated : 02-06-2015
HGNC name protein kinase D2
HGNC id 17293
Location 19q13.32      Physical location : 47.177.573 - 47.220.384
Synonym name serine/threonine-protein kinase D2
Synonym symbol(s) HSPC187, HSPC187, DKFZP586E0820, PKD2
EC.number 2.7.11.13
DNA
TYPE functioning gene
STRUCTURE 42.81 kb     19 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
NANOS2 19q13.32 nanos homolog 2 (Drosophila) NOVA2 19q13.3 neuro-oncological ventral antigen 2 LOC388554 19 similar to BC282485_1 PGLYRP 19q13.2-q13.3 peptidoglycan recognition protein LOC339346 19q13.33 similar to histidine secretory acid phosphatase LOC388555 19 similar to RPRC483 LOC126052 19q13.33 TGFB-induced factor (TALE family homeobox) pseudogene LOC147920 19q13.33 similar to VPRI645 LOC390944 19 similar to 60S ribosomal protein L12 UNQ644 19q13.33 APRG644 HIF3A 19q13.33 hypoxia inducible factor 3, alpha subunit PPP5C 19q13.3 protein phosphatase 5, catalytic subunit DKFZP564K0322 LOC390945 19 similar to paraneoplastic neuronal antigen MM2 FLJ10781 19q13.33 hypothetical protein FLJ10781 KIAA1183 19q13.33 KIAA1183 protein LOC390946 19 similar to Serine/threonine protein phosphatase 5 (PP5) (Protein phosphatase T) (PP-T) (PPT) LOC390947 19 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) CALM3 19q13.3 calmodulin 3 (phosphorylase kinase, delta) PTGIR 19q13.3 prostaglandin I2 (prostacyclin) receptor (IP) GNG8 19q13.2-q13.3 guanine nucleotide binding protein (G protein), gamma 8 MGC15476 19q13.33 thymus expressed gene 3-like PRKD2 19q13.2 thymus expressed gene 3-like STRN4 19q13.2 striatin, calmodulin binding protein 4 FKRP 19q13.33 fukutin related protein SLC1A5 19q13.3 solute carrier family 1 (neutral amino acid transporter), member 5 LOC390948 19 similar to heterogeneous nuclear ribonucleoprotein M isoform a; heterogenous nuclear ribonucleoprotein M4; N-acetylglucosamine receptor 1; M4 protein; heterogenous nuclear ribonucleoprotein M AP2S1 19q13.2-q13.3 adaptor-related protein complex 2, sigma 1 subunit GRLF1 19q13.3 glucocorticoid receptor DNA binding factor 1 NPAS1 19q13.2-q13.3 neuronal PAS domain protein 1 FLJ20512 19q13.33 hypothetical protein FLJ20512 C19orf7 19q13.33 chromosome 19 open reading frame 7 SAE1 19q13.33 SUMO-1 activating enzyme subunit 1 BBC3 19q13.3-q13.4 BCL2 binding component 3 DKFZP586M1019 LOC255783 19q13.33 hypothetical protein LOC255783
RNA
TRANSCRIPTS type messenger
text Variants 1, 2, and 3 encode the same isoform
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
19 splicing 3338 96.7 878 - 2008 18262756
19 splicing 3202 96.7 878 - 2008 18262756
17 splicing 2939 - 721 - 2008 18262756
18 splicing 3617 96.7 878 - 2008 18262756
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   highly
 thymus   highly
 tonsils   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • kinase domain
  • tyrosine kinase catalytic domain
  • a pleckstrin homology (PH) domain
  • C-terminal regulatory domain comprises two cysteine-rich domains (C1a/C1b), and PDZ-binding motifs that can target the kinases to distinct subcellular scaffolds through interactions with PDZ domain-containing proteins
  • HOMOLOGY
    Homologene
    FAMILY
  • Ser/Thr protein kinase family
  • PKD subfamily
  • CATEGORY receptor membrane G tyrosine kinase
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • phorbolester and growth factor stimulated protein kinase
  • implicated in the regulation of constitutive secretion in epithelial cells
  • controls the release of secretory granules in neuroendocrine tumour cells at the level of the Golgi apparatus
  • having a role in the proliferation and invasion of carcinoid tumors
  • having a role in controlling phorbol ester binding, catalytic activity, and nucleocytoplasmic shuttling
  • plays a role in numerous processes including cell proliferation, cell survival, immune cell signaling, gene expression, vesicle trafficking, and neuronal development
  • unlike PRKD1, PRKD2 catalytic activity is dispensable for normal embryogenesis
  • PRKD2 catalytic activity is, however, required for efficient antigen receptor-induced cytokine production in T-lymphocytes and for optimal T-cell-dependent antibody responses
  • a key role for PRKD2 in regulating the function of mature peripheral lymphocytes during adaptive immune responses
  • key signaling enzyme that mediate a range of physiologically important cellular responses
  • is a common signaling target downstream of various agonist receptors in platelets and G(q)-mediated signals along with calcium and novel PKC isoforms, in particular, PRKCD activate PRKD2 in platelets
  • novel role of RPKD1, PRKD2 as a regulator of RHOA activity and actin stress fiber formation through phosphorylation of rhotekin
  • has a restricted but critical role in T-cell antigen receptor signalling in mature T-cells
  • is involved in the regulation of PP2A activity in activated T cells through phosphorylation of Ser171 of SET
  • PRKD2 is a mediator of BCR-ABL transformation in chronic myelogenous leukemia
  • is essential for hypoxia-induced accumulation of HIF1A and activation of NFKB1 in tumor cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN
  • interaction between PRKD2 and LCK (LCK regulated the activity of PRKD2 by tyrosine phosphorylation, which in turn may have modulated the physiological functions of PKD2 during TCR-induced T cell activation)
  • expression and kinase activity of PRKD2 are required for the ligand-inducible stimulation of IFNAR1 ubiquitination and endocytosis and for accelerated proteolytic turnover of IFNAR1
  • phosphorylation of rhotekin by PRKD2 modulates the anchoring of the RHOA in the plasma membrane
  • GTP-RAB5C bound to ASAP1, and activation of RAB5C by EGFR signaling was necessary to promote the intracellular association of ASAP1 and PRKD2
  • is a functionally significant mediator of the effect of GABPA, GABPB1, GABPB2 on proliferation and apoptosis of BCR-ABL–expressing cells
  • PRKD2, mediated BCL6B gene expression by VEGFA stimulation
  • CIB1A is a novel mediator of PRKD2-driven carcinogenesis and a potentially interesting therapeutic target in cancer
  • MMP9 enhances PRKD2-mediated tumor angiogenesis by releasing extracellular matrix-bound VEGFA, increasing its bioavailability and angiogenesis
  • PRKD2 promotes glioma cell proliferation by regulating GOLPH3 and then AKT activation
  • HSP90 binds to and stabilizes PRKD2 in human cancer cells
  • cell & other
    REGULATION
    activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells
    activated in an agonist-specific manner in cardiomyocytes
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    leads to increased proliferation and invasion of BON endocrine cells
    tumoral     --over  
    in pancreatic cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    pharmacologic inhibition of PRKD2 may represent a valuable approach to targeting the leukemic stem cell (LSC) in CML
    cancerbrainglioma/neuroblstoma
    PRKD2-GOLPH3-AKT signaling pathway might be a potential glioma therapeutic target
    ANIMAL & CELL MODELS