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FLASH GENE
Symbol PRKD1 contributors: mct/ - updated : 15-01-2010
HGNC name protein kinase D1
HGNC id 9407
Location 14q12      Physical location : 30.045.688 - 30.396.899
Synonym name
  • protein kinase C, mu
  • protein kinase D
  • serine/threonine-protein kinase D1
  • Synonym symbol(s) PKD, PKCM, PRKCM, PKC-MU, PKD1
    EC.number 2.7.11.13
    DNA
    TYPE functioning gene
    STRUCTURE 351.21 kb     18 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 3679 - 912 - 2009 19581308
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  highly
     thyroid   highly
    Hearing/Equilibriumearinnercochlea highly
    Nervousbrain    
    Reproductivemale systemprostate   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Muscularstriatumskeletal predominantly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Muscularmyocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a cysteine-rich domain that comprises 2 domains, C1a and C1b
  • a pleckstrin homology domain
  • a kinase domain at the carboxy terminus, PDZ-binding motifs that can target the kinases to distinct subcellular scaffolds through interactions with PDZ domain-containing proteins
  • HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • CAMK Ser/Thr protein kinase family
  • PKD subfamily
  • CATEGORY signaling , receptor membrane serine/threonine
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    text
  • predominantly expressed in type I myofibers
  • basic FUNCTION
  • cytosolic serine-threonine kinase binding to the trans-Golgi network and regulating the fission of transport carriers specifically destined to the cell surface
  • inducing pre-T cell proliferation
  • implicated in the regulation of cell shape, adhesion, and migration
  • playing a role in actin remodelling
  • having a negative regulatory function in cell migration
  • regulates the dynamics of actin turnover through phosphorylation of proteins of the actin polymerization machinery, such as cortactin
  • key regulator of the cofilin signaling pathway thereby controlling actin remodeling and polarized cell motility in cervix carcinoma, breast cancer, and pancreatic cancer cells
  • role in contraction-induced SLC2A4 translocation and the combined actions of PRKD1 on TNNI3 phosphorylation and on SLC2A4 translocation would efficiently link accelerated contraction mechanics to increased energy production when the heart is forced to increase its contractile activity
  • highly effective class II HDAC kinase, and key regulator of skeletal muscle function
  • plays a role in numerous processes including cell proliferation, cell survival, immune cell signaling, gene expression, vesicle trafficking, and neuronal development
  • role in cardiomyocyte signal transduction through effects on class IIa HDACs
  • upstream regulator of cortactin (CTTN) and function in actin organization as well as cell migration
  • potentially important role in controlling cancer progression and metastasis
  • PRKD1-mediated phosphorylation of DLC1 on serine 807 negatively regulates DLC1 cellular function
  • key signaling enzyme that mediate a range of physiologically important cellular responses
  • novel role of RPKD1, PRKD2 as a regulator of RHOA activity and actin stress fiber formation through phosphorylation of rhotekin
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly interacts with F-actin, phosphorylates cortactin and negatively regulates cell migration
  • interacts and phosphorylates HSPB1
  • interaction with MYD88 (is essential for MYD88-dependent proinflammatory immune responses)
  • OSBP is a substrate of PRKD1 at the Golgi
  • serine 1884 is essential for the regulation of CACNA1C by PRKD1
  • cell & other
    REGULATION
    activated by activated in an agonist-specific manner in cardiomyocytes
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       gain of function
    PRKD1 activation impicated in the pathogenesis of cardiac hypertrophy and the evolution of heart failure syndromes
    constitutional   deletion    
    in Rett syndrome variant. probably with misregulation of the FOXG1 gene rather than a primary abnormality of PRKD1
    Susceptibility to muscular fatigue
    Variant & Polymorphism other genetic deletion in type I myofibers increases susceptibility to fatigue
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS