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FLASH GENE
Symbol PRKCQ contributors: mct/npt/pgu - updated : 23-10-2015
HGNC name protein kinase C, theta
HGNC id 9410
Location 10p15.1      Physical location : 6.469.104 - 6.622.238
Synonym symbol(s) RP11-563J2.1, PRKCT, PKC-theta, MGC126514, MGC141919
EC.number 2.7.11.13
DNA
TYPE functioning gene
STRUCTURE 153.15 kb     17 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
AKR1CL2 10p15.2 aldo-keto reductase family 1, member C-like 2 LOC389932 10 similar to 3-hydroxyhexobarbital dehydrogenase 1/3-alpha, 17-beta-hydroxysteroid dehydrogenase AKR1C1 10p15-p14 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) AKR1C2 10p15-p14 aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III) AKR1C3 10p15-p14 aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) LOC389933 10 similar to 3(20)alpha-hydroxysteroid/dihydrodiol dehydrogenase LOC340811 10p15.2 protein RAKc AKR1C4 10p15-p14 aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4) LOC389934 10 similar to protein RAKc UCN3 10p15.1 urocortin 3 (stresscopin) FLJ21665 10p15.1 hypothetical protein FLJ21665 NET1 10p15 neuroepithelial cell transforming gene 1 CALML5 10p15.1 calmodulin-like 5 CALML3 10pter-p13 calmodulin-like 3 ASB13 10p15.1 ankyrin repeat and SOCS box-containing 13 FLJ20360 10p15.1 hypothetical protein FLJ20360 GDI2 10p15 GDP dissociation inhibitor 2 ANKRD16 10p15.1 ankyrin repeat domain 16 FBXO18 10p15.1 F-box only protein, helicase, 18 IL15RA 10p15-p14 interleukin 15 receptor, alpha IL2RA 10p15-p14 interleukin 2 receptor, alpha SPF45 LOC387633 10 LOC387633 LOC142937 10p15.1 hypothetical protein BC008131 PFKFB3 10p15-p14 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 PRKCQ 10p15 protein kinase C, theta SFMBT2 10p15.1 Scm-related gene containing four mbt domains 2 FLJ14641 10p15.1 hypothetical protein FLJ14641 ITIH5 10p15.1 inter-alpha (globulin) inhibitor H5 ITIH2 10p15 inter-alpha (globulin) inhibitor, H2 polypeptide KIN 10p15-p14 KIN, antigenic determinant of recA protein homolog (mouse) ATP5C1 10q22-q23 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 TAF3 10p15.1 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa GATA3 10p15 GATA binding protein 3 LOC389935 10 similar to hypothetical protein FLJ14936
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 - 3286 - 706 - 2008 18086904
17 - 3097 - 643 - 2008 18086904
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Nervousbrain   moderately
Reproductivemale systemprostate  moderately
Respiratorylung   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticplasma    Homo sapiens
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticplatelet Homo sapiens
Lymphoid/ImmuneT cell Homo sapiens
cell lineage hematopoietic cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two zinc -dependant phorbol-ester and DAG binding domains
  • tyrosine kinase catalytic domain, and active kinase domain is required for retention of PRKCQ at the T cell immunological synapse
  • a V3 domain necessary and sufficient for localization to the immunological synapse mediated by association with the coreceptor CD28 and dependent on the kinase Lck
  • HOMOLOGY
    interspecies homolog to murine Prkcq
    Homologene
    FAMILY
  • protein kinase C (PKC) family of serine/threonine kinases
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • translocates to the center of the immunological synapse (
  • basic FUNCTION
  • serine/threonine kinase, critically involved in the regulation of differentiation and proliferation of T lymphocytes
  • its activation induces insulin-mediated vasoconstriction by inhibition of Akt and stimulation of ERK1/2 in muscle resistance arteries
  • PRKCQ-dependent oxidative signaling organelles involved in activation-induced T-cell death
  • cooperates with atypical PRKCZ and PRKCI in NF-kappaB transactivation of T lymphocytes
  • PRKCA and PRKCQ have overlapping functions in alloimmunoreactivity and both PRKCQ and PRKCA isotypes must be targeted to prevent organ allograft rejection
  • in regulatory T cells, inhibits their function and, intriguingly, is sequestered from the activating cellular interface
  • maintains the correct structure and function of the heart by preventing cardiomyocyte cell death in response to work demand and to neuro-hormonal signals
  • serine/threonine kinase that plays an essential role in antigen-regulated responses of T lymphocytes
  • implicated in several physiological processes regulating the activation response of platelets
  • involved in the regulation of hemostasis and thrombosis
  • critical TCR signaling molecule that promotes the activation and differentiation of naive T cells into inflammatory effector T cells
  • able to control T cell-mediated immune responses by shifting the balance between the differentiation of effector T cells and inhibitory Tregs
  • integrates the signals from TCR signaling and Th17 priming cytokines to upregulate STAT3 via NFKB and AP1, resulting in the stimulation of Th17 differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CD28 (for localization wihtin the immunologic synapse)
  • interaction with filamin A (required for T cell activation mediated by protein kinase C-theta)
  • established constituent of the immunological synapse, physically and functionally interacted with PRKCZ and PRKCI
  • crucial role of PRKCQ in positive selection of thymocytes in a pathway leading to the activation of ERK, AP1, NFAT, and NFkappaB
  • PRKCQ and CARD11 form a signalosome with TNFRSF4 in the immune synapse and play a major role in promoting maximum and prolonged NFKB activity mediated by TNFRSF4
  • KAT2A and EBF1 participate in regulation of PRKCQ gene expression in an opposite manner in immature B cells
  • to activate RAC1 and consequently PYGM, PRKCQ phosphorylates ARHGEF6 in T cells
  • in primary T cells, regulatory role of CORO1A on PRKCQ recruitment and function downstream of the TCR leading to NFKB1 transactivation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to rheumatoid arthritis
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyautoimmune 
    potential therapy target for the prevention and treatment of autoimmune and alloimmune disease states
    ANIMAL & CELL MODELS
  • the thymus of PKCtheta(-/-) mouse contains significantly less mature single positive T cells compared to wild-type controls