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FLASH GENE
Symbol PRKCI contributors: mct/npt/pgu - updated : 28-03-2013
HGNC name protein kinase C, iota
HGNC id 9404
Location 3q26.3      Physical location : 169.940.219 - 170.023.770
Synonym name
  • DNA segment, single copy, probe EST02087
  • atypical protein kinase C-lambda/iota
  • Synonym symbol(s) DXS1179E, PKCI, KPCI, MGC26534, nPKC-iota, APKC
    EC.number 2.7.11.13
    DNA
    TYPE functioning gene
    STRUCTURE 83.55 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map cen - DXS174 - DXS118 - DXS96 - DXS173 - DXS442 - BTK - GLA GLA - DXS178 - PRKCI - DXS265 - qter
    Authors (PMID: 7607695)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 4884 - 596 - 2008 17588663
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly
    Endocrineneuroendocrinepituitary  highly
    Nervousbrain   highly
    Respiratorylung   highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Muscularstriatumskeletal highly
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta moderatly
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • tyrosine kinase, catalytic domain
  • octicosapeptide repeat
  • a zinc-dependent phorbol-ester
  • DAG binding domain
  • HOMOLOGY
    interspecies homolog to C.elegans f09es.1
    homolog to prkcl
    intraspecies homolog to PRKCZ
    Homologene
    FAMILY
  • protein kinase superfamily
  • AGC Ser/Thr protein kinase family
  • PKC subfamily
  • CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • involved in the secretory response to nutrients
  • playing an essential role for protein transport in the early secretory pathway and required to promote RAB2-mediated vesicle budding at a vesicular tubular clusters subcompartment enriched in recycling cargo
  • might play a compensatory role in TCR/CD28-induced signaling
  • indirect co-regulator of HSF1 activity and the heat shock response
  • regulates primary dendrite specification of cerebellar Purkinje cells by localizing Golgi apparatus
  • PARD6B and PRKCI control mitotic spindle orientation in polarized epithelia and, furthermore, that PRKCI coordinately regulates multiple processes to promote morphogenesis
  • functions with CDC42 and PARD6B to control apical surface positioning
  • promotes proper spindle orientation through the phosphorylation of downstream substrates, and promotes cell survival in a kinase-dependent manner
  • expression of PRKCZ and PRKCI or both are dispensable for primitive and adult hematopoietic stem cell fate determination in steady-state and stress hematopoiesis
  • phosphorylates ROCK1 and suppresses its junctional localization, thereby allowing cells to retain normally shaped apical domains
  • phosphorylates NUMB to prevent its binding to CTNND1 and AP2A1, thereby attenuating CDH1 endocytosis to maintain apicobasal polarity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • PRKCI-PARD6A complex regulates the cytoplasmic localization of ECT2
  • like CDC42, the PARD6B/PRKCI complex controls mitotic spindle orientation during cell division to correctly position the nascent apical surface in a growing cyst (
  • FRMD6/PARD3-PRKCI-ROCK1 pathway that controls epithelial apical morphology
  • PAR polarity complex of PARD3, PARD6A, and an atypical protein kinase C (PRKCI) regulate several aspects of neuronal migration
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with RAB2
  • PNMA1
  • associates with CDK7
  • interacting with PRKCZ and PRKCQ
  • protects PARD6B from proteasomal degradation, mechanism ensuring that PARD6B is constitutively bound to and able to signal through PRKCI
  • interacting with WWC1 (WWC1 suppresses apical exocytosis through inhibition of PRKCI activity in epithelial cells)
  • interacting with CDC42 (CDC42 controls vascular network assembly through PRKCI during embryonic vasculogenesis)
  • RAC1 exchange factor TIAM1 participates in polarized cell migration with the PAR complex of PARD3, PARD6A, and PRKCI
  • PRKCI, interacts with TGFB1 receptors through PARD6A and these proteins localize to the leading edge of migrating cells
  • PARD6A-PRKCI recruitment to the premature apical membrane appears to be required for definition of apical identity of epithelial cells
  • CLASP2 directly interacted with PARD3 and was phosphorylated by PRKCI
  • cell & other
    REGULATION
    activated by lipids and Ca2+
    diacylglycerol which turn phosphorylates in a range of cellular proteins
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in esopageal squamous cell carcinoma with presence of lymph node metastasis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinflammatory 
    may constitute potential therapeutic targets for inflammatory joint diseases involving increased collagenase expression
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in esopageal squamous cell carcinoma with presence of lymph node metastasis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinflammatory 
    may constitute potential therapeutic targets for inflammatory joint diseases involving increased collagenase expression
    ANIMAL & CELL MODELS