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FLASH GENE
Symbol PRKCE contributors: mct/pgu - updated : 01-07-2014
HGNC name protein kinase C, epsilon
HGNC id 9401
Location 2p21      Physical location : 45.879.042 - 46.415.128
Synonym name nPKC-epsilon
Synonym symbol(s) PKCE, MGC125656, MGC125657, nPKC-epsilon
EC.number 2.7.11.1, 2.7.11.13
DNA
TYPE functioning gene
STRUCTURE 536.09 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
ZFP36L2 2p22.3 zinc finger protein 36, C3H type-like 2 MGC40574 2p22.1 hypothetical protein MGC40574 THADA 2p22.1 thyroid adenoma associated KIAA2028 2p22.1 similar to PH (pleckstrin homology) domain D2LIC 2p25.1-p24.1 dynein 2 light intermediate chain ABCG5 2p21 ATP-binding cassette, sub-family G (WHITE), member 5 (sterolin 1) ABCG8 2p21 ATP-binding cassette, sub-family G (WHITE), member 8 (sterolin 2) LRPPRC 2p21 leucine-rich PPR-motif containing PPM1B 2p22,1 protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform LOC391371 2 similar to 60S RIBOSOMAL PROTEIN L12 SLC3A1 2p16.3 solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1 FLJ23451 2p22.1 hypothetical protein FLJ23451 SIX3 2p21-p16 sine oculis homeobox homolog 3 (Drosophila) LOC388944 2 LOC388944 SIX2 2p16-p15 sine oculis homeobox homolog 2 (Drosophila) LOC151111 2p21 hypothetical LOC151111 FLJ10379 2p21 hypothetical protein FLJ10379 PRKCE 2p21 protein kinase C, epsilon EPAS1 2p21-p26 endothelial PAS domain protein 1 LOC388945 2 LOC388945 LOC388946 2 LOC388946 ATP6V1E2 2p21 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E isoform 2 ARHQ 2p21 ras homolog gene family, member Q PIGF 2p16 phosphatidylinositol glycan, class F CRIPT 2p21 phosphatidylinositol glycan, class F LOC388947 2 LOC388947 SOCS5 2p21 suppressor of cytokine signaling 5 LOC388948 2 hypothetical gene supported by BC062774 MCFD2 TTC7 2p21 tetratricopeptide repeat domain 7 FLJ40172 2p21 hypothetical protein FLJ40172 CALM2 2p21.3-p21.1 calmodulin 2 (phosphorylase kinase, delta) TACSTD1 2p21 tumor-associated calcium signal transducer 1 MSH2 2p22-p21 mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) KCNK12 2p22-p21 potassium channel, subfamily K, member 12 LOC285053 2p21 similar to ribosomal protein L18a; 60S ribosomal protein L18a LOC391372 2 similar to Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (P18) MSH6 2p16 mutS homolog 6 (E. coli) FBXO11 2p21-p16 F-box only protein 11
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 5537 - 737 - 2001 11179977
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   highly
Nervousbrain   highly
Reproductivemale systemtestis  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two zinc dependent phorbol-ester and DAG binding domains
  • one C2 domain for binding to acidic phospholipids in a calcium independent manner
  • HOMOLOGY
    interspecies homolog to murine Prkce
    Homologene
    FAMILY
  • protein kinase superfamily
  • Ser/Thr family of proteine kinase
  • PKC subfamily
  • CATEGORY signaling , receptor membrane serine/threonine
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • playing a pivotal role in endothelial cell cytoprotection against apoptosis
  • epsilon inhibits human CYP11B2 gene expression through ERK1/2 signaling pathway and JUNB
  • can induce distinctly different signaling from the Golgi and from the plasma membrane
  • role in regulating insulin inositide-dependent PLCG1 signalling in skeletal muscle differentiation
  • regulates BCL2 induction through activation of the transcription factor CREB1 (
  • role in contraction-stimulated SLC2A4 traffic in muscle cells
  • is likely a major signaling molecule that is involved in EDN1 induced positive inotropic effect in ventricular myocytes
  • regulates the N-ethylmaleimide-sensitive factor (NSF), an ATPase critical for membrane fusion events, and thereby promotes the trafficking of GABA(A) receptors
  • transforming oncogene and plays a pivotal role in numerous cellular processes including proliferation, invasion and differentiation
  • is the critical upstream molecule for EDN1-initiated contractility changes
  • EDN1 affects systolic Ca2+, and myofilament Ca2+ sensitivity and PRKCE is the upstream kinase involved in all of these intracellular regulatory processes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling sensory transduction/olfaction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • forms a signaling complex and acts co-operatively with AKT1 to protect vascular endothelial cells against apoptosis through induction of the anti-apoptotic protein BCL2 and inhibition of caspase-3 cleavage
  • activates AKT1 via DNA-dependent protein kinase (DNA-PK)to mediate its antiapoptotic function
  • interacts with NLRP5 in cumulus cells under physiological conditions (since PRKCE is known to collaborate with antiapoptotic signalling pathways, this suggests a novel mechanism for the function of NLRP5 in follicular maturation)
  • scaffold protein linking PLCG1 to the EGFR module, and acting as negative allosteric modulator of EGF receptor signalling
  • CTNND1 is a key effector of a RAS-PKCE oncogenic signaling axis
  • specific PRKCE activation directly stimulated MME activity, leading to degradation of a monomeric form of APP peptide and decreased APP neuronal toxicity
  • PDLIM5 could selectively recruit PRKCE to its specific substrate in neurons
  • cell & other
    REGULATION
    activated by EDN1 (is activated early and robustly following EDN1 stimulation and thus mediates multiple intracellular changes underlying the acute actions of EDN1 on myocardium)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in thyroid carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    is a tractable therapeutic target for triple negative breast cancer (TNBC)
    neurologyneurodegenerativealzheimer
    PRKCE activation may have therapeutic efficacy for AD by reducing neurotoxic APP accumulation as well as having direct anti-apoptotic and synaptogenic effects
    ANIMAL & CELL MODELS
    activation of two novel PKC isoforms (Prkcd and Prkce) and a classical PKC isoform (Prkca) during the development of steatohepatitis in mice fed the methionine- and choline-deficient (MCD) diet