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FLASH GENE
Symbol PRKAR2B contributors: mct - updated : 29-03-2008
HGNC name protein kinase, cAMP-dependent, regulatory, type II, beta
HGNC id 9392
Location 7q22      Physical location : 106.685.177 - 106.802.255
Synonym name
  • cAMP-dependent protein kinase type II-beta regulatory chain
  • Synonym symbol(s) PRKAR2
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 116.00 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 3678 - 418 - Mantovani (2008)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   highly
    Nervousnerve   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    two cyclic nucleotide binding domains
    secondary structure two regulatory chains and two catalytic chains
    mono polymer monomer , dimer
    HOMOLOGY
    interspecies homolog to murine Prkar2b
    Homologene
    FAMILY Camp-dependent kinase regulatory chain family
    CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • can act as a repressor of CREB transcriptional activity in T cells
  • may play an important role in regulating energy balance and adiposity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with CREB1 (interact with and suppress its transcriptional activity)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    aberrant levels of nuclear PRKAR2B in systemic lupus erythematosus T cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS