Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | PRKAR2A | contributors: mct - updated : 15-02-2023 |
HGNC name | protein kinase, cAMP-dependent, regulatory, type II, alpha |
HGNC id | 9391 |
|
Location | 3p21.31 Physical location : 48.788.092 - 48.885.270 |
Synonym name | |
| |
Synonym symbol(s) | PKR2, PRKAR2, MGC3606 |
EC.number | 2.7.11.1 |
DNA |
TYPE | functioning gene |
STRUCTURE | 103.28 kb 11 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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MAPPING | cloned | Y | linked | Y | status | confirmed |
Map | pter - D3S1322E - PRKAR2A , D3S3334 - D3S1581 - cen |
Authors | Tasken (98) |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | ubiquitous |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
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tissue |
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cell lineage
cell lines
| fluid/secretion
| highly ion lymph | |
at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
| |
motifs/domains
|
conjugated | Other |
mono polymer | heteromer , dimer , tetramer |
HOMOLOGY |
interspecies | homolog to rattus Prkar2a (89.6 pc) |
homolog to murine Prkar2a (89.2 pc) |
Homologene |
FAMILY |
CATEGORY | regulatory |
SUBCELLULAR LOCALIZATION | plasma membrane |
intracellular | |
intracellular,cytoplasm,cytosolic | |
intracellular,cytoplasm,cytoskeleton,microtubule,centrosome |
basic FUNCTION | |
| |
|
CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS | locomotion |
text | important for sperm mobility |
PATHWAY |
metabolism |
signaling | hormonal , signal transduction |
hormone-mediated signaling |
a component | |
|
INTERACTION |
DNA |
RNA |
small molecule | nucleotide, |
protein | |
|
cell & other |
REGULATION |
Other | inactive form composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules |
phosphorylated by the activated catalytic chain | |
acetylated |
ASSOCIATED DISORDERS |
corresponding disease(s) |
Other morbid association(s) |
|
Susceptibility |
Variant & Polymorphism
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Candidate gene
Marker
| Therapy target
|
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ANIMAL & CELL MODELS |