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FLASH GENE
Symbol PRKAR2A contributors: KTN/npt - updated : 03/12/2008
HGNC name protein kinase, cAMP-dependent, regulatory, type II, alpha
HGNC id 9391
Location 3p21.31      Physical location : 48.788.092 - 48.885.270
Synonym name
  • cAMP-dependent protein kinase regulatory subunit RII alpha
  • protein kinase A, RII-alpha subunit
  • Synonym symbol(s) PKR2, PRKAR2, MGC3606
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 97.18 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Map pter - D3S1322E - PRKAR2A , D3S3334 - D3S1581 - cen
    Authors Tasken (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2381 45.4 404 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepancreas exocrine   moderately
    Endocrineneuroendocrinepituitary  highly
     parathyroid   highly
    Lymphoid/Immunelymph node   moderately
    Reproductivefemale systemuteruscervix moderately
     female systembreastmammary gland moderately
     female systemovary  moderately
     male systemtestis  highly
    Respiratoryrespiratory tractlarynx  moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  moderately
    Connectivebone  moderately
    cell lineage
    cell lines
    fluid/secretion highly ion lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two cyclic nucleotide-binding domains
  • conjugated Other
    mono polymer heteromer , dimer , tetramer
    HOMOLOGY
    interspecies homolog to dog PRKAR2A (87.1 pc)
    homolog to cow PRKAR2A (95.4 pc)
    homolog to rattus Prkar2a (89.6 pc)
    homolog to murine Prkar2a (89.2 pc)
    homolog to chicken PRKAR2A (77.1 pc)
    Homologene
    FAMILY
  • cAMP-dependent kinase regulatory chain family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • being necessary for cAMP dependent modulation of ion channels
  • mediating membrane association by binding to anchoring proteins, including the MAP2 kinase
  • involved in the regulation of protein amino acid phosphorylation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS locomotion
    text important for sperm mobility
    PATHWAY
    metabolism
    signaling hormonal , signal transduction
    hormone-mediated signaling
    a component
  • inactive form of the enzyme is composed by two regulatory chains and two catalytic chains
  • active form : two active monomers and a regulatory dimer binding four cAMP
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • cAMP
  • protein
  • interacting with AKAP4 and CBFA2T3
  • cell & other
    REGULATION
    Other inactive form composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules
    phosphorylated by the activated catalytic chain
    acetylated
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS