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FLASH GENE
Symbol PRKAR2A contributors: mct - updated : 15-02-2023
HGNC name protein kinase, cAMP-dependent, regulatory, type II, alpha
HGNC id 9391
Location 3p21.31      Physical location : 48.788.092 - 48.885.270
Synonym name
  • cAMP-dependent protein kinase regulatory subunit RII alpha
  • protein kinase A, RII-alpha subunit
  • Synonym symbol(s) PKR2, PRKAR2, MGC3606
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 103.28 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure
  • SpI-III (GC) binding domains within the proximal promoter region of PRKAR2A gene may play important roles in modulating expression of the gene in human myometrial cells
  • MAPPING cloned Y linked Y status confirmed
    Map pter - D3S1322E - PRKAR2A , D3S3334 - D3S1581 - cen
    Authors Tasken (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 6492 45.4 404 - 1992 1618839
    10 - 6408 - 376 - 1992 1618839
    10 - 6426 - 382 - 1992 1618839
    12 - 2848 - 404 - 1992 1618839
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepancreas exocrine   moderately
    Endocrineneuroendocrinepituitary  highly
     parathyroid   highly
    Lymphoid/Immunelymph node   moderately
    Reproductivefemale systemuteruscervix moderately
     female systembreastmammary gland moderately
     female systemovary  moderately
     male systemtestis  highly
    Respiratoryrespiratory tractlarynx  moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  moderately
    Connectivebone  moderately
    cell lineage
    cell lines
    fluid/secretion highly ion lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two cyclic nucleotide-binding domains
  • conjugated Other
    mono polymer heteromer , dimer , tetramer
    HOMOLOGY
    interspecies homolog to rattus Prkar2a (89.6 pc)
    homolog to murine Prkar2a (89.2 pc)
    Homologene
    FAMILY
  • cAMP-dependent kinase regulatory chain family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    basic FUNCTION
  • being necessary for cAMP dependent modulation of ion channels
  • mediating membrane association by binding to anchoring proteins, including the MAP2 kinase
  • involved in the regulation of protein amino acid phosphorylation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS locomotion
    text important for sperm mobility
    PATHWAY
    metabolism
    signaling hormonal , signal transduction
    hormone-mediated signaling
    a component
  • inactive form of the enzyme is composed by two regulatory chains and two catalytic chains
  • active form : two active monomers and a regulatory dimer binding four cAMP
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • cAMP
  • protein
  • interacting with AKAP4 and CBFA2T3
  • . Ca2+-dependent interaction between S100A1 and PRKAR2A represents a novel mechanism that provides a link between Ca2+ and PKA signaling, which is important for the regulation of gene expression in skeletal muscle via HDAC4 cytosolic-nuclear trafficking
  • cell & other
    REGULATION
    Other inactive form composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules
    phosphorylated by the activated catalytic chain
    acetylated
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with RAF1 in melanomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Prkar2a (-/-) and Prkar2a (+/-) mice frequently developed hematopoietic neoplasms dominated by histiocytic sarcomas (HS) with rare diffuse large B cell lymphomas (DLBCL)