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FLASH GENE
Symbol PRKACB contributors: SGE/mct - updated : 18-11-2020
HGNC name protein kinase, cAMP-dependent, catalytic, beta
HGNC id 9381
Corresponding disease
PPAVSD2 postaxial polydactyly with atrioventricular septal defect (AVSD) 2
Location 1p31.1      Physical location : 84.543.744 - 84.704.179
Synonym symbol(s) PKAC-beta, MGC9320, MGC41879, DKFZp586F2323, DKFZp781I2452
EC.number 2.7.1.37/ 2.7.11.11
DNA
TYPE functioning gene
STRUCTURE 160.42 kb     10 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 4481 - 398 - 2001 11589697
  • PRKACB1
  • 10 - 4496 - 351 - 2001 11589697
  • PRKACB2
  • 9 - 1968 - 257 - 2001 11589697
  • PRKACB3
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node    
     thymus    
    Nervousbrain    
    Urinarybladder    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • phosphorylating a large number of substrates in the cytoplasm and the nucleus
  • may be playing a more subtle role in memory that is modulated by strain-specific genetic modifiers
  • PRKACA and PRKACB encode the principal catalytic (C) subunits of protein kinase A (PKA) Calpha and Cbeta, respectively
  • PRKACA, PRKACB playing critical role in human development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TAL1 together with hematopoietic transcription factors RUNX1 and GATA1 binds to the promoter of the isoform 3 of PRKACB
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PPAVSD2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation     gain of function
    in cortisol-producing adenomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS