Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PRIMA1 contributors: mct/npt - updated : 17-05-2010
HGNC name proline rich membrane anchor 1
HGNC id 18319
Location 14q32.12      Physical location : 94.184.643 - 94.254.766
Synonym name
  • acetylcholinesterase membrane anchor precursor PRIMA
  • membrane anchor of acetylcholinesterase
    • Synonym symbol(s) PRIMA
    DNA
    TYPE functioning gene
    STRUCTURE 70.12 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 3668 - 153 - Xie (2010)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemovary  highly
    Visualeye   moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a proline-rich attachment domain (PRAD) binding the ACHE catalytic subunits
  • cytoplasmic domain of PRIMA1 play some role in stabilizing the raft localization of ACHE (Xie 2010)
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    text synapses
    basic FUNCTION
  • required to anchor acetylcholinesterase (ACHE) to the basal lamina of the neuromuscular junction and to the
    • membrane of neuronal synapses in brain
  • also able to organize ACHE into tetramers
  • involved in the neurotransmitter catabolism
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • in the brain anchoring ACHE in cell membranes (Xie 2010)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       gain of function
    significantly up-regulated in the differentiated neurons (Xie 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS