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FLASH GENE
Symbol PRIM2 contributors: SGE/npt - updated : 14-04-2008
HGNC name primase, DNA, polypeptide 2 (58kDa)
HGNC id 9370
Location 6p11.2      Physical location : 57.182.421 - 57.513.375
Synonym name
  • primase, polypeptide 2A, 58kDa
  • DNA primase large subunit
  • polypeptide 2A, p58
  • Synonym symbol(s) PRIM2A, MGC75142, dJ422B11.1.1, p58
    EC.number 2.7.7.-
    DNA
    TYPE functioning gene
    STRUCTURE 330.95 kb     14 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 2353 58 509 - Weiner (2007)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Reproductivefemale systemovary  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four putative cysteine ligands
  • an iron-sulfur cluster in DNA primase that contributes to enzymatic activity
  • C-terminal 67 amino acid residues of the p180 subunit are essential for SV40 DNA replication as they are required for binding of the p68 subunit and play a role in the interaction with the primase subunits, p48 and p58
  • mono polymer heteromer , dimer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
  • eukaryotic-type primase large subunit family
  • CATEGORY enzyme , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication
  • CELLULAR PROCESS nucleotide, replication
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • subunit of the pol alpha (POLA)/primase complex
  • heterodimer of a small subunit and a large subunit
  • heterotetrameric complex essential for simian vacuolating virus 40 (SV40) DNA replication
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with XRCC1 (LÚvy 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS