Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | PRICKLE1 | contributors: mct/npt/shn - updated : 17-02-2014 |
HGNC name | prickle homolog 1 (Drosophila) |
HGNC id | 17019 |
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Corresponding disease |
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Location | 12q12 Physical location : 42.852.140 - 42.983.572 | ||
Synonym name | |||
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silencer factor)-interacting LIM domain protein | |||
Synonym symbol(s) | FLJ31627, FLJ31937, RILP, MGC138902, MGC138903, EPM1B |
DNA |
TYPE | functioning gene |
STRUCTURE | 131.43 kb 8 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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MAPPING | cloned | Y | linked | N | status | provisional |
Map | cen - D12S1592 - D12S1653 - PRICKLE1 - D12S1301 - D12S1663 - qter |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | widely |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
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tissue |
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cells |
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cell lineage
cell lines
| hematological malignancies cell lines | fluid/secretion
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at STAGE |
physiological period | fetal |
Text | heart, eyes, lens, eye anterior segment, optic nerve, retina, retina foveal and macular, RPE and choroid |
life cycle |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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HOMOLOGY |
interspecies | ortholog to Prickle1, Mus musculus |
ortholog to PRICKLE1, Pan troglodytes | |
ortholog to Prickle1, Rattus norvegicus | |
ortholog to prickle1a, Danio rerio |
intraspecies | homolog to PRICKLE2 |
Homologene |
FAMILY |
CATEGORY | regulatory |
SUBCELLULAR LOCALIZATION | intracellular |
intracellular,cytoplasm,organelle,membrane | |
intracellular,cytoplasm,cytosolic | |
intracellular,nucleus | |
text | |
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basic FUNCTION | |
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CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling |
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a component |
INTERACTION |
DNA |
RNA |
small molecule |
protein | |
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cell & other |
REGULATION |
Phosphorylated by | MINK1 (MINK1 phosphorylates and regulates its RAB5-dependent endosomal trafficking, a process required for the localized plasma membrane accumulation and function of PRICKLE1) |
ASSOCIATED DISORDERS |
corresponding disease(s) | EPM1B |
Other morbid association(s) |
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Susceptibility | to neural tube defects (NTDs) |
Variant & Polymorphism other | |
Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |