basic FUNCTION
| regulator of ossification |
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regulator of intimal cell growth |
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mucin-like proteoglycan that is a major lubricant in articulating joints |
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superficial zone protein (SZP), an important joint lubricant produced by superficial zone, that are more responsive to stimulation by catabolic cytokines such as IL1 (Taniguchi 2009) |
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synovial glycoprotein that has been shown to be a boundary lubricant (Gleghorn 2009) |
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brain-specific integral membrane protein implicated in neuronal plasticity, such as filopodia formation and axon growth after brain lesion (Broggini 2010) |
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having lubricating and protective actions in joints |
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critical protective factor in articular joints, is implicated in hematopoietic progenitor cell expansion and megakaryopoiesis |
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may have a role in normal disc posterior attachment physiology through the prevention of cellular adhesion as well as providing lubrication during normal bilaminar zone function |
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is likely able to bind to polymorphonuclear granulocytes (PMN) via an L-selectin-dependent and -independent manner and may play a role in PMN-mediated inflammation |
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PRG4 presence significantly reduces friction between the cornea and conjunctiva and its deficiency may play a role in promoting corneal damage |
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important role of PRG4 in mediating interactions at the cartilage surface is to attach to the cartilage surface |
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PRG4 (lubricin) is a novel putative ligand for CD44 and may control synoviocyte overgrowth in inflammatory arthropathies via a CD44-mediated mechanism |
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mucinous glycoprotein secreted by synovial fibroblasts and superficial zone chondrocytes, that has a homeostatic multifaceted role in the joint |
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plays an important role in regulating the inflammatory environment under both homeostatic and tissue injury states |
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serves as a lubricant in joints, tendons and visceral cavities (pleural cavity, pericardium) and inhibits synovial proliferation |
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plays a role in controlling inflammation and pain as well as being a mechanical lubricant |
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adult talar cartilage increases both the PRG4 release and biosynthetic activity as an immediate cellular response to injury |